Dexmedetomidine for Pediatric Anesthesia
This trial is testing two different amounts of a sedative drug called Dexmedetomidine in young children. The goal is to see if it reduces the amount of another anesthetic, Sevoflurane, needed during surgery. Dexmedetomidine helps calm the patient and reduces stress, which means less Sevoflurane is required. Dexmedetomidine has been studied extensively for its sedative effects in children, showing benefits in reducing the required dose of other anesthetics like Sevoflurane.
Behavioural Intervention
Anesthesia-Induced Dreaming for PTSD
This trial aims to test if anesthesia-induced dreaming can help reduce symptoms of PTSD. Participants will be split into two groups - one that will experience dreaming during anesthesia and one that will not.
Procedure
Lower Oxygen Concentration for Preventing Collapsed Lung
This trial aims to study whether using a lower oxygen concentration (70% compared to 100%) before removing a breathing tube reduces the risk of lung tissue collapse (atelectasis) in patients under anesthesia
Incretin Mimetic
Holding vs. Continuing Incretin-Based Therapies for Type 2 Diabetes
This trial aims to see if stopping incretin-based therapy before endoscopy can reduce the chances of having too much food in the stomach. The main things they are looking at are: - The
My Anesthesia Choice for Hip Fracture
This trial aims to evaluate a strategy to improve shared decision-making between doctors and patients regarding anesthesia options for hip fracture surgery at 6 US hospitals. The strategy involves using a 1-page conversation aid and
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Trials for Local Anesthesia Patients
Procedure
Opioid-free general anesthetic for Chronic Pain
The objective of this trial is to determine whether an opioid-free general anesthetic (OFA) technique utilizing ketamine, dexmedetomidine, and lidocaine infusions can help reduce postoperative pain in opiate-dependent chronic pain patients (CPPs) undergoing spine surgery when compared with traditional opioid-containing techniques. It is expected that this OFA regimen will have a measurable reduction on postoperative opioid consumption and pain scores in CPPs.
Corticosteroid
Remifentanil for Anesthesia
The primary aim is to utilize near-infrared spectroscopy (NIRS) in patients under general anesthesia to measure changes in brain blood flow in the bilateral somatosensory cortices and the prefrontal cortices in response to noxious stimulation.
Procedure
Standard Intravenous Regional Anesthesia (IVRA) with Reapplication of Esmarch for Hand Injuries and Disorders
Intravenous regional anesthesia is a commonly used technique in the outpatient setting for short hand and upper extremity cases, such as carpal tunnel release or trigger finger release. The technique requires a tourniquet, Esmarch bandage, an intravenous line, and lidocaine. It can be performed and learned easily. The technique is safe and easy to perform, and it provides adequate anesthesia for short cases; however, there are still some cases in which adequate anesthesia is not achieved. One of the possible reasons for failure is that the local anesthetic (lidocaine) does not properly exit the veins to reach the interstitial space (where many nerves are located) to provide the nerve block. In this study, the investigators hypothesize that after application of lidocaine to the intravenous system, application of external pressure through the skin will facilitate tissue penetration and improve the block. The only research procedure being done is a re-application of the Esmarch bandage; all other procedures are Standard of Care.
Trials for General Anesthesia Patients
Procedure
Opioid-free general anesthetic for Chronic Pain
The objective of this trial is to determine whether an opioid-free general anesthetic (OFA) technique utilizing ketamine, dexmedetomidine, and lidocaine infusions can help reduce postoperative pain in opiate-dependent chronic pain patients (CPPs) undergoing spine surgery when compared with traditional opioid-containing techniques. It is expected that this OFA regimen will have a measurable reduction on postoperative opioid consumption and pain scores in CPPs.
Corticosteroid
Remifentanil for Anesthesia
The primary aim is to utilize near-infrared spectroscopy (NIRS) in patients under general anesthesia to measure changes in brain blood flow in the bilateral somatosensory cortices and the prefrontal cortices in response to noxious stimulation.
Corticosteroid
Anesthesia Types for Cancer Surgery
This trial is testing two ways to keep patients asleep during cancer surgery: one using an IV drug called propofol and the other using inhaled gases. It aims to see which method is better at reducing the risk of death from any cause. Propofol is a widely used intravenous anesthetic known for its potential effects on cancer outcomes.
Local Anesthetic
Bupivacaine +2 More for Lidocaine
Mohs surgery is a very effective option in removing non-melanoma skin cancers, as the tissue being removed is analyzed the same day. If there are remnants of cancer cells in the tissue removed, the Mohs surgeon will go back and remove further tissue and repair the surgical wound all within the same day. Unfortunately, postoperative pain is quite prevalent among patients requiring Mohs procedures, as up to 52% require an additional oral pain medication. Lidocaine is the most commonly used anesthetic used in Mohs given its rapid onset of action. However, the duration of lidocaine's effect is much shorter than bupivacaine, which may translate into increased postoperative pain. To date, there are no specific studies comparing bupivacaine alone, lidocaine alone or both in conjunction in Mohs procedures. The investigators predict bupivacaine alone and bupivacaine used in conjunction with lidocaine are more effective in managing pain during Mohs surgery than lidocaine alone. To test our hypothesis, the investigators plan to have 105 patients receive either lidocaine alone, bupivacaine alone, or lidocaine and bupivacaine in conjunction during their Mohs procedure. Pain will be evaluated at various time points throughout the surgery.
Phase 3 Trials
Fentanyl for Low Blood Pressure
This trial will test whether or not fentanyl contributes to hypotension (low blood pressure) during the induction of general anesthesia in elderly patients. If fentanyl is found to contribute to hypotension, the study may lead to a change in clinical practice which could improve patient outcomes and mortality rates.
Procedure
Opioid-free general anesthetic for Chronic Pain
The objective of this trial is to determine whether an opioid-free general anesthetic (OFA) technique utilizing ketamine, dexmedetomidine, and lidocaine infusions can help reduce postoperative pain in opiate-dependent chronic pain patients (CPPs) undergoing spine surgery when compared with traditional opioid-containing techniques. It is expected that this OFA regimen will have a measurable reduction on postoperative opioid consumption and pain scores in CPPs.
Trials With No Placebo
Face Tent Ventilation System for Risk Reduction During Pediatric Surgeries
This trial will test how well a local exhaust ventilation system (LEVS) works to reduce exposure to infectious and smoke particulates for medical providers during anesthesia-related AGMPs and pediatric surgeries.
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Frequently Asked Questions
Introduction to anesthesia
What are the top hospitals conducting anesthesia research?
When it comes to cutting-edge research in the field of anesthesia, several top hospitals are leading the way. In Chicago, Rush University Medical Center is at the forefront with three ongoing anesthesia trials. While they may not have a historical record of anesthesia trials, their dedication to advancing knowledge and improving patient care is evident. Similarly, Stanford University in Stanford, Royal University Hospital in Saskatoon, Washington University School of Medicine in Saint Louis, and Massachusetts General Hospital in Boston all have three active anesthesia trials but no prior history. These institutions are committed to exploring new techniques and medications to enhance the safety and efficacy of anesthesia procedures.
Anesthesia plays a crucial role in modern medicine by ensuring patients' comfort during surgical procedures or relieving pain for various medical interventions. The research conducted at these esteemed hospitals contributes to refining current practices while opening avenues for novel approaches that can revolutionize patient care. From investigating new anesthetic agents to studying innovative delivery methods and monitoring technologies, these ongoing clinical trials offer hope for advancements that will benefit patients worldwide.
Located amidst Chicago's vibrant medical community, Rush University Medical Center serves as a hub for groundbreaking research on anesthesia. Meanwhile,in California stands Stanford University- world-renowned for its contributions across multiple disciplines; now adding their expertise towards enhancing anesthesiology through rigorous studies on such critical topics.In Canada,Royal university hospital based out of Saskatoon focuses its resources toward shaping future standards within this specialty by spearheading pioneering projects.Across midwest region liesThe Washington university school of medicine located right at St.Louis where experts strive collectively striving hard pushing boundaries cultivating path-breaking discoveries contributing towards field progression.Finally situated amidst rich legacy & academic excellenceisMassachusetts general hospital nestled within heartlandofBoston holding significant acclaim globally encompassesa myriad auspicious endeavors aimedat forging breakthroughs through intrepid efforts--no exception when it comes downtoanesthesia clinical investigations
These hospitals represent beacons of innovation and collaboration within the realmofanesthesiology. By conducting these trials, theyare paving the way for safer and more effective anesthetic techniques, ultimately improving patient outcomes and transforming the landscape of anesthesia practice.
Which are the best cities for anesthesia clinical trials?
Boston, Massachusetts; Houston, Texas; and New york, New York emerge as the top cities for anesthesia clinical trials. With 15 ongoing studies in Boston focusing on areas like individualization of neuromuscular blockade and EEG monitoring, along with 10 active trials each in Houston and New York exploring various aspects of general anesthesia and other related interventions. These cities offer ample opportunities for individuals to participate in cutting-edge research that aims to advance the field of anesthesia and improve patient outcomes.
Which are the top treatments for anesthesia being explored in clinical trials?
Anesthesia research is thriving, with several exciting treatments currently under investigation in clinical trials. Leading the way is dexmedetomidine, a drug showing promise in six active anesthesia trials. Another contender gaining attention is remimazolam, which has four ongoing clinical trials dedicated to exploring its potential as an anesthetic agent. Lastly, sufentanil remains a trusted option, with three active trials investigating its efficacy and safety profile for anesthesia purposes. These innovative treatments hold great potential to revolutionize the field of anesthesia and enhance patient care globally.
What are the most recent clinical trials for anesthesia?
Exciting advancements are occurring in the field of anesthesia, with recent clinical trials exploring various approaches and interventions. One such trial investigates the efficacy of inhalational anesthesia, aiming to enhance patient outcomes during surgical procedures. Gebauers Ethyl Chloride 100% Topical Spray is also being studied as a potential anesthetic option, providing an alternative to traditional methods. Additionally, ongoing research explores different anesthesia procedures and their impact on patient comfort and safety. Another trial focuses on the use of high-dose Danavorexton as a means to improve anesthesia effectiveness. These innovative studies contribute valuable insights to optimize anesthesia practices and ultimately enhance patient care across medical settings
What anesthesia clinical trials were recently completed?
Recently, several noteworthy clinical trials in the field of anesthesia have concluded, shedding light on new possibilities for medical practice. These studies focused on exploring and evaluating different approaches to anesthesia administration and management. The trial findings provide valuable insights that can contribute to enhancing patient safety, optimizing pain control strategies, and improving overall surgical outcomes. By advancing our understanding of anesthesia techniques, these completed trials pave the way for future advancements in perioperative care.