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Alpha-2 Adrenergic Agonist

Phase 1: Atipamezole & caffeine's in a 1:1 ratio for Emergence From Anesthesia

Phase 1
Waitlist Available
Research Sponsored by University of Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up this test will be repeated every 15 minutes for 90 minutes after the subject has awakened]
Awards & highlights

Study Summary

This trial looks at whether Atipamezole & caffeine can help people wake up from anesthesia. Each person will visit the University of Chicago 4 times, the first for consent, the second for a physical exam, and then 2 times for sedation sessions.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~this test will be repeated every 15 minutes for 90 minutes after the subject has awakened]
This trial's timeline: 3 weeks for screening, Varies for treatment, and this test will be repeated every 15 minutes for 90 minutes after the subject has awakened] for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
The time when the drug injections are complete to the awakening of the subject.
Secondary outcome measures
Measure Cognitive Function
Measure Reaction Time

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Phase 1: Atipamezole & caffeine's in a 1:1 ratioActive Control1 Intervention
Is this arm, subjects will be randomized to IV administration of Atipamezole & caffeine's in a 1:1 ratio
Group II: Phase 1: Precedex & Saline in a 1:1 ratioPlacebo Group1 Intervention
Is this arm, subjects will be randomized to receive IV administration of Precedex & Saline in a 1:1 ratio

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

University of ChicagoLead Sponsor
1,004 Previous Clinical Trials
819,791 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Have any prior investigations been conducted on the effects of a one-to-one ratio of Atipamezole and caffeine?

"Currently, there are 122 ongoing studies for Phase 1: Atipamezole & caffeine's in a 1:1 ratio, with 25 trials having reached the third phase. Most of these clinical trials take place in Karachi, Sindh but there is an additional 327 locations running similar experiments."

Answered by AI

What potential safety concerns exist with the use of a 1:1 ratio combination of atipamezole and caffeine among individuals?

"Our team at Power assessed the safety of 1:1 ratio of Atipamezole and caffeine to be a score of 1 due to limited evidence for its efficacy in this Phase 1 trial."

Answered by AI

Is a spot available for me to participate in this medical experiment?

"This clinical trial seeks 56 participants between the ages of 22 and 39 who have recently been anesthesized. Eligibility criteria necessitates these conditions be met in order to qualify for enrollment."

Answered by AI

Are those aged 50 or more being included in the recruitment process for this research?

"The parameters for inclusion in this clinical trial necessitate that participants must be between 22 and 39 years of age. Simultaneously, there are 38 trials available to those under 18, as well as 68 trials open to people aged 65 or above."

Answered by AI

Are there available slots for individuals to join this research project?

"This research is no longer recruiting participants, as the trial was first posted on April 1st 2023 and last updated July 12th 2022. Patients who are seeking other studies should be aware that currently there is one study exploring emergence from anesthesia, while 122 Phase 1 trials with Atipamezole & caffeine in a 1:1 ratio actively enrolling patients."

Answered by AI

To what extent is this research project being embraced by participants?

"Recruiting for this particular trial has ceased. Originally posted on April 1st 2023 and last edited in July 12th 2022, it is no longer seeking participants. If interested, there are currently one study investigating emergence from anesthesia and 122 Phase 1 trials monitoring the effects of Atipamezole & caffeine's in a 1:1 ratio that require volunteers."

Answered by AI

What purpose do physicians typically prescribe the combination of atipamezole and caffeine in a 1:1 ratio?

"Respiratory distress, pain, and ocular-related issues can be addressed with a 1:1 mixture of Atipamezole & caffeine during Phase 1."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Turning Dexmedetomidine Into a Powerful Anesthetic That Can be Rapidly and Completely Reversed
2023. "Turning Dexmedetomidine Into a Powerful Anesthetic That Can be Rapidly and Completely Reversed". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04942340.
~0 spots leftby Apr 2026
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