Behavioral Intervention
Group Psychodynamic Interpersonal Psychotherapy for Binge Eating Disorder
Binge Eating Disorder (BED) affects as many as 3% of women and men in Ontario, 8% of obese individuals, and 30% to 50% of those participating in weight loss programs. BED, the most common eating disorder, is characterized by over-eating with loss of control (i.e., binge eating), but with no purging (e.g., vomiting).Our previous research indicates that the total health care costs for women with BED is 36% higher than the Canadian average for women of a similar age, and that health care costs significantly decreased following intensive treatment at our Centre. The main goal of our study is to inform the development of a stepped care approach to the treatment of BED. Stepped care involves providing easily accessible low intensity treatment first, and then providing more expensive intensive treatment second, if necessary. The second goal is to assess if a second more intensive step of treatment provides added value. Although stepped care for BED is suggested by a number of clinicians and researchers, no study adequately tests predictors of who might benefit from minimal treatment alone and who would require the more intensive second step. The results of this study will guide decision making regarding who benefits from stepped care, and will help to increase the accessibility, availability, and cost effectiveness of psychological treatments for BED.
Behavioural Intervention
Behavioral Therapy for Eating Disorders
This trial is designed to study the independent and combined effects of four components of mindfulness-based behavioral therapy on eating pathology. The four components are Mindful Awareness, Distress Tolerance, Emotion Modulation, and Values-Based Decision Making. The trial will compare the efficacy of each component when used alone and in combination with standard behavioral treatment for bulimia nervosa and binge eating disorder. The primary aim of the study is to evaluate the independent efficacy of each treatment component on eating pathology. Secondary aims are to test the hypotheses that the efficacy of each component is moderated by related baseline deficits in self-regulation, and to quantify the component interaction
Compassionate Letter-Writing for Eating Disorders
This trial tests if writing self-compassionate letters can help patients with eating disorders feel less shame and be kinder to themselves. Participants will write these letters for a short period before starting their regular treatment. This approach aims to build self-compassion and reduce shame, which are believed to contribute to the maintenance and alleviation of eating disorders.
Behavioural Intervention
Cognitive Behavioural Therapy-Ten +1 More for Eating Disorders
This trial will compare two types of cognitive behavioural therapy for people with eating disorders who are not underweight. The goal is to see which therapy is more effective and has less drop-out.
Behavioral Intervention
Family Based Treatment +1 More for Anorexia Nervosa
The goals of this project are to 1) develop training opportunities for master's-level and pre-doctoral psychology students in evidence-based assessment and treatment of adolescent EDs; 2) to provide the healthcare workforce, including licensed health professionals such as primary care physicians and behavioral health interventionists, with knowledge and competence to recognize early symptoms of and intervention strategies for EDs; and 3) to test the efficacy of delivering two evidence-based treatments for adolescent eating disorders, Family Based Treatment (FBT) and Enhanced Cognitive Behavioral Therapy (CBT-E), in the home-based setting.
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Trials for Anorexia Nervosa Patients
Brain Stimulation + Cognitive Training for Anorexia
"This trial is studying adults with restrictive eating disorders who are getting outpatient treatment to see if a new brain stimulation technique called transcranial direct current stimulation (tDCS) can improve brain training. Participants
Behavioral Intervention
Facing Eating Disorder Fears for Anorexia Nervosa
This trial tests a therapy called FED-F that helps people with Anorexia Nervosa face their fears about food, weight, and social situations. The goal is to see if this approach can reduce anxiety and prevent relapse by encouraging patients to confront their fears.
Behavioural Intervention
Personalized Treatment vs Cognitive Behavioral Therapy for Eating Disorders
This trial is testing a new, personalized treatment for eating disorders (ED), which may be more effective than the current gold-standard treatment. The study goals are to develop and test the new treatment, and to see if it works by targeting specific areas identified in each individual's network.
Trials for ED Patients
Behavioral Intervention
Facing Eating Disorder Fears for Anorexia Nervosa
This trial tests a therapy called FED-F that helps people with Anorexia Nervosa face their fears about food, weight, and social situations. The goal is to see if this approach can reduce anxiety and prevent relapse by encouraging patients to confront their fears.
Behavioural Intervention
Personalized Treatment vs Cognitive Behavioral Therapy for Eating Disorders
This trial is testing a new, personalized treatment for eating disorders (ED), which may be more effective than the current gold-standard treatment. The study goals are to develop and test the new treatment, and to see if it works by targeting specific areas identified in each individual's network.
Support Group for Caregivers for Eating Disorders
This trial is researching the impact of the COVID-19 pandemic on children with eating disorders and their families, as well as the feasibility of virtual parent-led peer support groups to help mitigate the impact of the pandemic.
Behavioural Intervention
Self-Help Intervention for Eating Disorders
This trial is testing a mobile app intervention for teens with eating disorders who are not currently receiving treatment. The app includes simplified language and tailored content relevant to adolescent issues, and a social networking feature designed to facilitate group exchanges. The goal is to improve eating disorder symptoms among teens not currently engaged in treatment.
Trials With No Placebo
Online Program for Body Dysmorphic Disorder
This trial will test if a one-time online program can help people feel better about their bodies. The program asks participants to think about society's standards of beauty and challenge them. Participants will answer questions about
Behavioral Intervention
Facing Eating Disorder Fears for Anorexia Nervosa
This trial tests a therapy called FED-F that helps people with Anorexia Nervosa face their fears about food, weight, and social situations. The goal is to see if this approach can reduce anxiety and prevent relapse by encouraging patients to confront their fears.
Behavioural Intervention
Personalized Treatment vs Cognitive Behavioral Therapy for Eating Disorders
This trial is testing a new, personalized treatment for eating disorders (ED), which may be more effective than the current gold-standard treatment. The study goals are to develop and test the new treatment, and to see if it works by targeting specific areas identified in each individual's network.
Visual feedback of symptom frequency for Bulimia
This study has two aims: 1) to test the validity of an eating disorder symptom checklist against an established clinical interview; and 2) to examine whether providing eating disorder patients with visual graphs of their symptom frequency in the early sessions of active treatment will lead to higher numbers of patients achieving a "rapid response" (65% reduction in symptoms in the first 4 weeks of treatment). Groups where patients receive visual graphs of symptom frequency will be compared with groups where patients do not receive visual graphs of symptom frequency on rates of rapid response to cognitive behavior treatment for eating disorders.
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Frequently Asked Questions
Introduction to eating disorder
What are the top hospitals conducting eating disorder research?
In the realm of eating disorders, several hospitals are making significant strides in clinical trials to better understand and treat these complex conditions. In New york, the Department of Psychiatry's Eating and Weight Disorders Program is leading the way with three ongoing trials focused on eating disorders. While they may not have any completed studies to their name just yet, their dedication to research shows promise for future breakthroughs. Similarly, at Yale's Department of Psychiatry in New Haven, researchers are actively conducting three clinical trials centered around eating disorders but also lack any past records of completed studies.
Philadelphia's Drexel University takes part in this pursuit as well with two active eating disorder trials being carried out at Stratton Hall. With no all-time trial data available either, it is evident that cutting-edge research is underway at this institution. Meanwhile, at Lindner Center of HOPE in Mason another renowned facility dedicated to mental health care shares a similar focus by currently engaging in two ongoing clinical investigations within the realm of eating disorders.
Lastly but certainly not least Mayo Clinic located in Rochester has demonstrated its commitment through an active trial and a notable milestone—their first recorded eating disorder study took place back 2012 marking their initiation into this field. These institutions collectively showcase an unwavering dedication to unraveling the complexities surrounding various types of disordered eating behaviors prevalent among many individuals today.
These hospitals play a vital role in advancing our understanding and treatment options for those affected by these challenging conditions. Through collaboration between medical professionals and patients participating in these groundbreaking trials we hope to see innovative approaches emerge that will ultimately enhance quality of life for countless individuals grappling with debilitating effects associated with eating disorders while bridging path towards brighter future
Which are the best cities for eating disorder clinical trials?
When it comes to eating disorder clinical trials, several cities offer opportunities for individuals seeking innovative treatments and interventions. Boston, Massachusetts, stands out with 4 active trials exploring TNX-1900, Cognitive Behavioral Therapy (CBT), the Diabetes Body Project, and more. New York City also offers 4 ongoing studies focusing on participants without Bulimia Nervosa, Parent Education and Patient Coaching, Interoceptive Exposure Treatment (IE), among others. Providence, Rhode island, boasts 3 active trials centered around Family-Based Treatment and iACT Experimental Intervention. In Hamilton, Ontario there are 3 active trials involving a Support Group for Caregivers and Self-Compassionate Letter-Writing Intervention. Lastly, New Haven in Connecticut has 3 active trials investigating LDX and Naltrexone/Bupropion as potential treatment options. These cities provide promising avenues for those interested in participating in cutting-edge research aimed at improving outcomes for individuals with eating disorders.
Which are the top treatments for eating disorder being explored in clinical trials?
Clinical trials are uncovering promising treatment options for eating disorders, offering hope for those affected by these conditions. Leading the way is Cognitive-Behavioral Therapy (CBT), a widely-studied approach that helps individuals address unhealthy thoughts and behaviors associated with their eating disorder. Another key player in clinical trials is Family-Based Treatment (FBT), which involves families actively participating in therapy to support their loved one's recovery process. Additionally, researchers are exploring the potential benefits of Dialectical Behavior Therapy (DBT), focusing on developing skills to regulate emotions and improve interpersonal relationships as part of the treatment process for eating disorders.
What are the most recent clinical trials for eating disorder?
Recent clinical trials offer hope in the field of eating disorders, with potential advancements in treatment and support. One such trial is TNX-1900, a Phase 2 study that investigates its effectiveness in addressing eating disorders. Additionally, Naltrexone Hydrochloride has shown promise as it progresses through Phase 2 and 3 trials to evaluate its efficacy for treating these conditions. Psychotherapy also remains an important avenue being explored through Phase 2 trials, aiming to enhance therapeutic interventions. Although Solriamfetol's Phase 4 trial concluded earlier, it still holds relevance due to its potential impact on managing eating disorders. Lastly, research into the combined effects of Morning Light Version and Melatonin offers valuable insights during their ongoing Phases 1 and 2 studies. These clinical trials represent significant strides towards improving outcomes for individuals affected by eating disorders.
What eating disorder clinical trials were recently completed?
Recently, several clinical trials focused on eating disorders have reached completion, showcasing advancements in this critical area of research. Ongoing efforts to better understand and treat these complex conditions are yielding promising results. Notably, a trial investigating the effectiveness of a new therapy for anorexia nervosa concluded successfully, marking significant progress towards improved treatment options. Another study exploring innovative interventions for binge eating disorder also reached completion recently, highlighting the commitment to finding effective strategies for individuals affected by this condition. These completed trials provide hope and inspire further exploration into understanding and addressing eating disorders more effectively.