Meal Timing for Metabolism
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to examine how the timing of eating changes how the body makes and uses energy (metabolism). This study will also examine if metabolism changes with age.
Do I need to stop my current medications for the trial?
The trial requires that you have not used melatonin, psychoactive, hypnotic, stimulant, or pain medications (except occasionally), or beta blockers within the past month. If you are currently using these, you may need to stop before participating.
Is meal timing generally safe for humans?
Research on meal timing, such as eating late or early, shows it can affect hunger, energy use, and metabolism, but there are no reports of serious safety concerns for humans. These studies suggest that while meal timing can influence weight and metabolic health, it is generally safe for people to participate in such trials.12345
How does the 'Meal Timing for Metabolism' treatment differ from other treatments for weight management?
The 'Meal Timing for Metabolism' treatment is unique because it focuses on the timing of meals in relation to the body's internal clock, rather than just the quantity or type of food consumed. This approach considers how eating at different times of the day can affect metabolism and weight, potentially offering a novel way to manage weight by aligning meal times with the body's natural rhythms.36789
What data supports the effectiveness of the treatment Early Total Caloric Intake, Extended Overnight Fast, Late Total Caloric Intake for metabolism?
Who Is on the Research Team?
Eve Van Cauter, PhD
Principal Investigator
University of Chicago
Are You a Good Fit for This Trial?
This trial is for healthy overweight or obese adults aged 30-75 with a BMI between 25 and less than 40, who sleep between 6.5 to 9 hours nightly within specific hours. Excluded are those with dietary restrictions, certain blood conditions, diabetes, unstable medical issues, recent surgeries or clinical study participation, menopause or pregnancy in women, and various medication uses.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Assessment of habitual sleep, meal timing, and caloric distribution under real-life conditions
Intervention
Participants undergo a 6-day semi-ambulatory inpatient intervention with different caloric distribution models
Post-Intervention Assessment
Repeat short laboratory session to assess changes in metabolic and cardiovascular profiles
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Early Total Caloric Intake
- Extended Overnight Fast
- Late Total Caloric Intake
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Chicago
Lead Sponsor
National Institute on Aging (NIA)
Collaborator
Northwestern University
Collaborator