Time-Restricted Eating for Cognitive Health in Obesity
Trial Summary
Will I have to stop taking my current medications?
Yes, you may need to stop taking certain medications. The trial excludes participants who are currently using anabolic medications, certain antidepressants, antipsychotic agents, and other specific drugs. It's best to discuss your current medications with the trial team to see if they are allowed.
What data supports the effectiveness of the treatment Time-Restricted Eating for Cognitive Health in Obesity?
Research suggests that time-restricted eating (TRE) can lead to weight loss and improvements in metabolic health, which may indirectly support cognitive health. Additionally, a study found that early time-restricted eating (eTRE) improved cognitive acuity in university students, indicating potential cognitive benefits.12345
Is time-restricted eating safe for humans?
Time-restricted eating (TRE), a form of intermittent fasting, has been studied in humans and generally appears safe, with no adverse effects on mood, sleep quality, or cognitive performance in short-term studies. However, more extensive and long-term research is needed to confirm its safety across diverse populations.13467
How does time-restricted eating differ from other treatments for obesity?
Time-restricted eating (TRE) is unique because it focuses on limiting the time window for eating each day, rather than restricting calories or specific foods. This approach aligns eating patterns with the body's natural circadian rhythms, potentially improving metabolic health and aiding weight loss without the need for strict dietary changes.23678
What is the purpose of this trial?
Grounded in the principles of geroscience, the proposed Fasting ENHANCE study will test whether a time restricted eating (TRE) regimen can improve cognitive function and other aspects of successful aging in a safe and sustainable manner in at risk overweight older adults. Specifically, this study will evaluate whether TRE can improve cognitive and physical function, as well as self-reported sleep, mood, and quality of life, in overweight, older adults (age \> 65 years) who are at high risk of cognitive decline due to self-reported cognitive difficulties. Eligible participants will be assigned to either a TRE intervention, in which they will be instructed to fast for a target of 16 hours per day, or a successful aging (SA) comparison group for a 24-week period.
Research Team
Stephen Anton
Principal Investigator
University of Florida
Eligibility Criteria
This trial is for overweight older adults (age > 65) with a BMI over 25 and some self-reported cognitive difficulties. They should not have severe diseases like heart disease, diabetes, or neurologic conditions, nor be on certain medications that interfere with fasting.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are assigned to either a Time Restricted Eating (TRE) intervention or a Successful Aging (SA) comparison group for a 24-week period
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Successful Aging Comparison Group (LEARN)
- Time Restricted Eating intervention
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Florida
Lead Sponsor
Florida Department of Health, Ed and Ethel Moore Alzheimer's Disease Research Program
Collaborator