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Immunotherapy + Chemotherapy + Radiation for Glioblastoma
Study Summary
This trial is testing a combination of immunotherapy, chemotherapy, and radiation therapy to treat patients with glioblastoma.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I have not taken any antibiotics in the last 2 weeks.I am not receiving any other cancer treatments while on this study.I have active tuberculosis.I have not had signs of infection in the last 2 weeks.I do not have any health conditions that would make it unsafe for me to take a new drug.I expect to need a major surgery during the study.I had surgery for my condition and have not received any treatment since.I have had cancer treatments directly in the tumor area but not Gliadel wafers or Optune device.I will start treatment within 6 weeks after my surgery.I agree to use birth control during the study.I do not have any serious health issues that would prevent me from following the study's procedures.I am currently being treated for an infection.I haven't taken any immune-boosting drugs in the last 6 weeks or five half-lives of the drug.I've had a brain MRI within the last 2 weeks and am on a low or reducing dose of steroids.I haven't had any other cancers in the last 5 years, except for those considered low risk and curable.My diagnosis is grade IV glioma, confirmed by tissue analysis.I am mostly able to care for myself and carry out daily activities.I have not had severe infections or been hospitalized for infection complications in the last 4 weeks.I have not received a live vaccine in the last 4 weeks and do not plan to during the study.I haven't taken any immune-weakening medications in the last 2 weeks.My kidney function, measured by creatinine levels, is within the normal range.I am a woman who can have children and have a recent negative pregnancy test.I am using two birth control methods or am not having sex to avoid pregnancy during the study.I haven't had any other cancers in the last 5 years, except for those considered low risk and curable.I have a history of lung scarring or inflammation.I have multiple brain tumors that need different treatment areas.I have been treated with drugs targeting PD-1 or PD-L1.I have a history of HIV or active hepatitis B or C.I have a lung condition not caused by an infection.
- Group 1: Adjuvant phase (temozolomide, atezolizumab)
- Group 2: Concurrent phase (temozolomide, atezolizumab, RT)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What types of ailments are commonly addressed by Radiation Therapy?
"Radiation Therapy is a viable treatment for many conditions, including advanced directives and small cell lung cancer (SCLC). It can also be used to combat the progression of disease in combination with pharmacotherapy."
Is this an unprecedented clinical research endeavor?
"Presently, 554 Radiation Therapy studies are underway across 1812 cities in 74 nations. The initial trial occurred back in 2002, when Schering-Plough conducted a Phase 2 drug approval study on 60 patients. Since then, 472 clinical trials have concluded their testing phases."
Are there any openings for individuals to participate in this research study?
"As per clinicaltrials.gov, this research study is not presently accepting new participants. Initially posted on June 30th 2017 and last updated on September 14th 2022, the trial unfortunately does not require additional enrollees at this time; however there are 997 other trials actively seeking volunteers right now."
What is the participant count of this research endeavor?
"This investigation has concluded its recruitment phase, with the trial's initial post on June 30th 2017 and last edit falling on September 14th 2022. Should you be seeking additional clinical research opportunities, there are 443 studies involving glioblastoma currently accepting enrolment as well as 554 Radiation Therapy trials that remain open for participation."
What other research endeavors have been conducted concerning Radiation Therapy?
"Currently, 554 Radiation Therapy trials are in progress with 94 of them being Phase 3 studies. Houston is the hub for most research related to this therapeutic approach; however, it can be accessed at 23116 sites around the country."
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