← Back to Search

Corticosteroid

Anesthesia Types for Cancer Surgery (GA-CARES Trial)

Phase 4

Waitlist Available

Research Sponsored by Stony Brook University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients with known or suspected cancer and scheduled to undergo any of the following oncologic surgical procedures: Lobectomy or pneumonectomy, Esophagectomy, Radical (total) cystectomy, Pancreatectomy, Partial hepatectomy, Hyperthermic intraperitoneal chemotherapy (HIPEC), Gastrectomy (subtotal or total), Cholecystectomy or bile duct resection

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 years

Awards & highlights

GA-CARES Trial Summary

This trial is comparing two types of anesthesia during cancer surgery - one using propofol and the other using a volatile agent (sevoflurane, isoflurane, or desflurane). The goal is to see which is better at preventing death.

Who is the study for?

The GA-CARES trial is for adult cancer patients undergoing specific surgeries like lung, esophagus, bladder, pancreas removal or certain chemo procedures. It's not for those under 18, with a very short life expectancy, severe health issues (ASA Class 5), egg/soy allergies, or sensitivity to anesthesia.Check my eligibility

What is being tested?

This study compares two ways of keeping people asleep during cancer surgery: using propofol through an IV or inhaling agents like sevoflurane. The goal is to see which method affects survival rates after surgery.See study design

What are the potential side effects?

Propofol may cause low blood pressure, pain at the injection site and can lead to a rare but serious condition called Propofol Infusion Syndrome. Inhaled agents might lower blood pressure and heart rate and could cause nausea or vomiting after waking up.

GA-CARES Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am scheduled for a major cancer surgery, such as lung, esophagus, bladder, pancreas, liver, stomach removal or specific chemotherapy.

GA-CARES Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

All-cause mortality

Secondary outcome measures

All-cause mortality as a binary outcome

Recurrence free survival

GA-CARES Trial Design

2Treatment groups

Experimental Treatment

Group I: Volatile agentExperimental Treatment1 Intervention

Maintenance of general anesthesia with volatile agent (sevoflurane, desflurane, or isoflurane)

Group II: Propofol infusionExperimental Treatment1 Intervention

Maintenance of general anesthesia with propofol infusion

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Propofol

2017

Completed Phase 4

~1530

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Stony Brook UniversityLead Sponsor

213 Previous Clinical Trials

37,723 Total Patients Enrolled

Media Library

Propofol (Corticosteroid) Clinical Trial Eligibility Overview. Trial Name: NCT03034096 — Phase 4

General Anesthesia Research Study Groups: Propofol infusion, Volatile agent

General Anesthesia Clinical Trial 2023: Propofol Highlights & Side Effects. Trial Name: NCT03034096 — Phase 4

Propofol (Corticosteroid) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03034096 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What clinical applications is Propofol commonly employed for?

"Propofol is a pharmacological agent that can effectively treat sedation during medical procedure, monitored anesthesia care therapy, and sedative therapy."

Answered by AI

Are there any open enrollment opportunities for this clinical experiment?

"This trial is no longer accruing any more patients. It was initially posted on January 31, 2017 and the last modification to its parameters occurred on October 13, 2022. If you're searching for alternatives, there are 2390 trials that are enrolling volunteers with surgical oncology and 72 studies actively seeking participants that involve Propofol."

Answered by AI

Is Propofol a viable option when considering patient safety?

"Propofol is a proven medical intervention that has been granted approval, so Power rated its safety at 3 on our scale."

Answered by AI

What is the current size of the participant pool in this medical experiment?

"Sadly, this trial has concluded its recruiting efforts. It was posted on January 31st 2017 and last updated October 13th 2022. However, there are still 2390 trials that focus on surgical oncology and 72 studies investigating the use of Propofol actively admitting patients."

Answered by AI

What is the geographic scope of this trial's implementation?

"Currently, the study is being conducted at 5 different sites, two of which are in Buffalo and New Hyde Park. To reduce commuting time if you decide to be a part of this trial, it's best to pick a location closest to you."

Answered by AI

Is there a precedent for research on the efficacy of Propofol?

"Presently, there are 72 ongoing clinical trials studying the efficacy of Propofol with 12 in their final Phase 3 stages. Jinan, Shandong is a prominent location for these studies; however, 251 sites worldwide have opened investigations into this drug's effects."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

General Anesthetics in CAncer REsection Surgery (GA-CARES) Trial

Elliott Bennett-Guerrero 2017. "General Anesthetics in CAncer REsection Surgery (GA-CARES) Trial". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03034096.

All > Anesthesia