Diet Changes for Food Allergy
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores a new method to identify foods causing Eosinophilic esophagitis (EoE), a condition where the esophagus becomes inflamed, making swallowing difficult. Researchers aim to determine if a special blood test can accurately identify problem foods like milk, soy, egg, and wheat, compared to the usual method of endoscopy, which uses a flexible tube to examine the esophagus. Participants will follow an assay-directed diet change, an elimination diet based on test results, to manage their EoE. This trial suits those diagnosed with EoE who have not yet identified their trigger foods and are willing to adjust their diet. As an unphased trial, it offers patients a unique opportunity to contribute to groundbreaking research that could simplify and improve EoE management.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but if you are on immunomodulatory therapy (like steroids or chemotherapy) for more than 4 weeks, you may not be eligible to participate.
What prior data suggests that this assay-directed diet change is safe for patients with EoE?
Research shows that changing one's diet is a common way to manage Eosinophilic esophagitis (EoE). Studies have found that these changes can help reduce harmful cells in the esophagus and are usually safe for short-term use. However, in a study of 15 adults who tried elimination diets based on allergy tests, 67% did not achieve the desired results. This indicates that while the diet was generally safe, it did not work for everyone.
For those considering this treatment, diet changes are a standard and generally safe way to manage EoE, though results can vary. It is crucial to consult a healthcare provider before making significant dietary changes.12345Why are researchers excited about this trial?
Researchers are excited about the assay-directed diet change for managing Eosinophilic Esophagitis (EoE) because it offers a personalized approach to treatment. Unlike standard therapies like corticosteroids or proton pump inhibitors, which address symptoms, this method aims to identify and eliminate specific foods causing the allergic reaction. By targeting the root cause, the diet change could lead to more effective and sustainable management of EoE, potentially reducing the need for long-term medication.
What evidence suggests that assay-directed diet changes are effective for EoE?
Research shows that elimination diets can help people with Eosinophilic esophagitis (EoE), a condition where certain foods cause the esophagus to swell. Studies have found that removing four specific foods from the diet can lead to improvement in about 54% of adults with EoE. Another review found that different diet plans often succeed in reducing symptoms and improving the condition. However, skin tests have not been very effective in identifying foods to avoid. In this trial, participants will follow a new test-based approach that aims to better identify problem foods, potentially offering a more effective way to manage EoE through diet.678910
Who Is on the Research Team?
David A Hill, MD, PhD
Principal Investigator
Children's Hospital of Philadelphia, University of Pennsylvania
Are You a Good Fit for This Trial?
This trial is for individuals with food allergies, specifically those who may have Eosinophilic esophagitis (EoE). Participants should be willing to undergo diet changes based on assay results and standard-of-care practices. The eligibility criteria details are not fully provided.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo blood tests and follow a personalized elimination diet based on T cell assay results and standard-of-care practices
Follow-up
Participants are monitored for changes in symptoms and esophageal eosinophilia through surveys and endoscopy
What Are the Treatments Tested in This Trial?
Interventions
- Assay directed diet change
Find a Clinic Near You
Who Is Running the Clinical Trial?
Children's Hospital of Philadelphia
Lead Sponsor
American Partnership for Eosinophilic Disorders
Collaborator
Food Allergy Fund
Collaborator