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Cancer Screening for Colorectal Cancer
N/A
Waitlist Available
Led By Christine D Berg
Research Sponsored by National Cancer Institute (NCI)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up events through 13 years of follow-up or through december 31, 2009; median follow-up 12.1 years.
Awards & highlights
Study Summary
This trial is testing whether cancer screening methods can reduce deaths from prostate, lung, colon, rectum, or ovarian cancer.
Who is the study for?
This trial is for men and women aged 55 to 74 who haven't had certain cancer screenings in the past three years. It's not for those with a history of specific cancers, major organ removals, or current cancer treatment (except some skin cancers). Women who've had both ovaries removed could join after October 1996.Check my eligibility
What is being tested?
The study tests if sigmoidoscopy (a procedure to look inside the lower part of the large intestine) and a screening questionnaire can help detect colorectal cancer early and reduce death rates from this disease.See study design
What are the potential side effects?
Sigmoidoscopy may cause discomfort, bleeding, or rarely perforation of the colon. The screening questionnaire has no physical side effects but may involve time commitment and privacy considerations.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ one year from screening examination
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~one year from screening examination
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Colorectal Cancer Death Rates
Colorectal Cancer Deaths
Secondary outcome measures
Colorectal Cancer Incidence
Colorectal Cancer Incidence Rates
Complications of Diagnostic Evaluation Following a Positive Screening Test
+4 moreTrial Design
2Treatment groups
Active Control
Group I: Colorectal ScreeningActive Control2 Interventions
Participants undergo a colorectal examination with a flexible sigmoidoscope at baseline and year 5. Participants complete a DQX at baseline and DHQ at year 3. An ADU (previously referred to as the PSH questionnaire) is mailed to each participant annually for 13 years to identify all prevalent and incident colorectal cancers as all deaths that occur among both screened and control subjects during the trial.
Group II: ControlActive Control1 Intervention
Participants receive standard medical care. Participants complete a DHQ at baseline.
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Who is running the clinical trial?
National Cancer Institute (NCI)Lead Sponsor
13,654 Previous Clinical Trials
40,778,253 Total Patients Enrolled
Christine D BergPrincipal InvestigatorNational Cancer Institute (NCI)
3 Previous Clinical Trials
309,802 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am a male who has not taken Proscar, Propecia, or finasteride in the last 6 months.You cannot participate if you are already involved in another trial for cancer screening or prevention.I have had cancer in my colon, rectum, lung, prostate, or PLCO-related cancers.I am a man taking Tamoxifen and can participate in the trial.I had both ovaries removed before October 1996.I am under 55 or over 75 years old.I have had surgery to remove my entire colon, one lung, or my entire prostate.I am currently being treated for cancer, not including basal or squamous skin cancer.I am a male who has had multiple PSA tests in the last 3 years.I have taken Tamoxifen or Evista/Raloxifene but can still participate.
Research Study Groups:
This trial has the following groups:- Group 1: Colorectal Screening
- Group 2: Control
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What are the essential goals of this clinical research?
"This clinical trial aims to measure Colorectal cancer Deaths over a 13-year period, with an estimated median follow up of 12.1 years. Secondary endpoints include Colorectal Cancer Incidence, determined through medical record abstraction; as well as the associated incidence rate and deaths from all causes between those in the screening arm and usual care arm."
Answered by AI
Does this experiment still require participants to join?
"According to clinicaltrials.gov, the search for participants in this trial is not active at present. Initially posted on November 16th 1993 and updated last June 30th 2022, there are currently 2640 other studies actively enrolling patients."
Answered by AI
Are my qualifications sufficient to partake in this clinical investigation?
"This trial, which is recruiting up to 154900 participants, requires that applicants suffer from colonic carcinoma and lie between the ages of 55-74."
Answered by AI
Are individuals aged 18 and over eligible to become participants in this trial?
"According to the qualifying requirements for this research, participants should be between 55 and 74 years of age. There are 79 clinical trials available to minors while those over 65 have access to 2618 studies."
Answered by AI
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