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Exercise Training for Fat Metabolism in Postmenopausal Women

N/A

Recruiting

Led By Robert C Hickner, PhD

Research Sponsored by Florida State University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg/dL, or 2hr OGTT blood glucose 140 to 199 mg/dL)

Postmenopausal (50-70 yrs.)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 12 weeks of resistance or endurance training

Awards & highlights

Study Summary

This trial will study how well resistance training improves fat metabolism in postmenopausal women with obesity and pre-diabetes, to see if it could help prevent type 2 diabetes.

Who is the study for?

This trial is for postmenopausal women aged 50-70, who are obese with a BMI of 30-39.9 and have prediabetes. They should not be smokers or currently on hormone replacement therapy, and must be relatively inactive (not exercising more than twice a week). Women with certain medical conditions or taking medications affecting fat metabolism cannot participate.Check my eligibility

What is being tested?

The study aims to compare the effects of resistance exercise versus endurance exercise on fat metabolism in postmenopausal women at risk for type 2 diabetes. It will assess how these exercises can influence body weight maintenance by altering the balance between fat breakdown and synthesis.See study design

What are the potential side effects?

While specific side effects are not listed, typical risks associated with physical activity may include muscle soreness, fatigue, joint stress, and increased heart rate during exercise. Participants will likely be monitored for any adverse reactions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My blood sugar levels indicate I have prediabetes.

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I am a woman aged 50-70 and have gone through menopause.

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My BMI is between 30 and 39.9, indicating obesity.

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I am a woman aged 50-70 and have gone through menopause.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 12 weeks of resistance or endurance training

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~12 weeks of resistance or endurance training

This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks of resistance or endurance training for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change from baseline gluteal adipose tissue glycerol concentration at 12 weeks

Change from baseline subcutaneous abdominal adipose tissue glycerol concentration at 12 weeks

Change from baseline whole-body lipolysis at 12 weeks

Secondary outcome measures

Change in adipogenesis

Change in blood flow as measured by ethanol concentrations in dialysate samples from subcutaneous abdominal adipose tissue

Change in blood growth hormone concentrations

+4 more

Trial Design

2Treatment groups

Experimental Treatment

Group I: Resistance ExerciseExperimental Treatment1 Intervention

Participants do regular resistance exercise for 12 weeks.

Group II: Endurance ExerciseExperimental Treatment1 Intervention

Participants do regular endurance exercise for 12 weeks.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Endurance Exercise

2012

N/A

~160

Resistance Exercise

2017

Completed Phase 4

~880

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

Florida State UniversityLead Sponsor

199 Previous Clinical Trials

31,571 Total Patients Enrolled

16 Trials studying Obesity

1,298 Patients Enrolled for Obesity

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH

2,358 Previous Clinical Trials

4,315,121 Total Patients Enrolled

446 Trials studying Obesity

588,818 Patients Enrolled for Obesity

Pennington Biomedical Research CenterOTHER

304 Previous Clinical Trials

181,316 Total Patients Enrolled

64 Trials studying Obesity

117,445 Patients Enrolled for Obesity

Media Library

Endurance Exercise Clinical Trial Eligibility Overview. Trial Name: NCT05351476 — N/A

Obesity Research Study Groups: Resistance Exercise, Endurance Exercise

Obesity Clinical Trial 2023: Endurance Exercise Highlights & Side Effects. Trial Name: NCT05351476 — N/A

Endurance Exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT05351476 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Do I satisfy the criteria for participating in this medical experiment?

"The present clinical trial is looking for 120 participants in the age range of 50 to 70 who have obesity. To be eligible, potential candidates must possess these characteristics: female gender, postmenopausal (50-70 years old), obese BMI (30-39.9 kg/m2), prediabetes blood sugar levels (HbA1c 5.7 - 6.4%, fasting glucose 100 to 125 mg/dL or 2 hour OGTT 140 to 199 mg/dL), lack of regular exercise training (> 20 minutes per day twice a week) , no smoking habit and having abstained from hormone replacement therapy for two years prior"

Answered by AI

Does this medical trial accept participants aged 45 or over?

"This particular clinical trial is restricted to participants aged between 50 and 70. However, there are an additional 205 studies available for those below 18 years of age, as well as 717 trials accessible to individuals above 65."

Answered by AI

What objectives is this trial attempting to accomplish?

"During the 12-week trial, researchers will assess change in gluteal adipose tissue glycerol concentration from baseline as a primary outcome. Secondary outcomes include measurements of blood flow using ethanol concentrations in dialysate samples from subcutaneous abdominal adipose tissue, ratio of 13CO2 to 12CO2 levels detected in breath samples, and dialysate ethanol data collected through microdialysis probes inserted into subcutaneous gluteal adipose tissue."

Answered by AI

Does this research project have any open slots for participants?

"Correct. The details available on clinicaltrials.gov demonstrate that this medical trial, which was originally posted in May of 2020, is actively recruiting participants. Approximately 120 patients need to be enrolled from a single centre."

Answered by AI

To what extent is the participant pool expanding for this investigation?

"Affirmative. Clinicaltrials.gov documents this clinical trial to be actively enrolling participants, having been initially posted on May 20th 2022 and last updated July 20th 2022. The study will include 120 individuals from a single medical centre."

Answered by AI