Study Summary
This trial will compare the effects of a home-based exercise program to no exercise program in people who have had surgery.
- Frailty
- Surgery Complications
- Physical Disabilities
Treatment Effectiveness
Effectiveness Progress
Study Objectives
2 Primary · 12 Secondary · Reporting Duration: Participants are asked to reflect on the program during a call the day before surgery.
Trial Safety
Safety Progress
Side Effects for
Trial Design
2 Treatment Groups
Control Group
1 of 2
Exercise Group
1 of 2
Active Control
Experimental Treatment
750 Total Participants · 2 Treatment Groups
Primary Treatment: Exercise Group · No Placebo Group · N/A
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18+ · All Participants · 4 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:- McIsaac, Daniel I, Dean A Fergusson, Rachel Khadaroo, Amanda Meliambro, John Muscedere, Chelsia Gillis, Emily Hladkowicz, and Monica Taljaard. 2022. “PREPARE Trial: A Protocol for a Multicentre Randomised Trial of Frailty-focused Preoperative Exercise to Decrease Postoperative Complication Rates and Disability Scores”. BMJ Open. BMJ. doi:10.1136/bmjopen-2022-064165.
- McIsaac DI, Fergusson DA, Khadaroo R, Meliambro A, Muscedere J, Gillis C, Hladkowicz E, Taljaard M; PREPARE Investigators. PREPARE trial: a protocol for a multicentre randomised trial of frailty-focused preoperative exercise to decrease postoperative complication rates and disability scores. BMJ Open. 2022 Aug 8;12(8):e064165. doi: 10.1136/bmjopen-2022-064165.
- 2020. "The PREPARE Trial: Exercise Before Surgery to Improve Recovery in Older People With Frailty". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04221295.
Frequently Asked Questions
What is the intended outcome of this investigation?
"This research endeavour aims to gauge patient disability levels after 30 days of post-operative recovery. Additional objectives include surveying mortality rates, safety (adverse events) and health system discharge position. Falls, cardiac or respiratory issues and unplanned healthcare providence will be monitored for the exercise group while control participants must report any falls from enrollment onwards. Unforeseen medical experiences are also scrutinised during enrolment to pre-operation day in the intervention cohort via chart analysis." - Anonymous Online Contributor
Are there any limitations on the number of participants in this observational research?
"Indeed, the information available on clinicaltrials.gov reveals that this experiment is recruiting participants currently; it was initially posted on February 24th 2020 and its details were last modified at the end of November 2022. This trial seeks out 750 individuals from a single medical facility." - Anonymous Online Contributor
Is enrollment for this trial still open to new applicants?
"Affirmative, the clinicaltrials.gov website states that recruitment is ongoing for this medical trial. It was first listed on February 24th 2020 and most recently edited on November 29th 2022 with a goal of enrolling 750 patients at 1 site." - Anonymous Online Contributor