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Exercise for Colorectal Cancer (EXACT Trial)

N/A
Waitlist Available
Led By Justin C Brown, Ph.D.
Research Sponsored by Pennington Biomedical Research Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Completed chemotherapy (if applicable)
Age ≥18 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 12 weeks
Awards & highlights

EXACT Trial Summary

This trial will look at how exercise may help keep colorectal cancer from coming back in people who have finished treatment.

Who is the study for?
This trial is for adults over 18 who've finished treatment for stage I-III colorectal cancer and aren't very active, doing less than 90 minutes of moderate exercise a week. They can't be planning major surgery during the study or have other active cancers (except certain skin cancers), be in another weight loss or diet study, have metastatic colon cancer, weigh more than 181 kg, or have conditions that make exercising unsafe.Check my eligibility
What is being tested?
The trial is testing if moderate-intensity aerobic exercise helps prevent colorectal cancer from coming back after treatment. Participants will either start an exercise program right away or be put on a wait-list while researchers track their health outcomes.See study design
What are the potential side effects?
Since this trial involves moderate exercise as the intervention, side effects might include typical workout-related issues like muscle soreness, fatigue, and risk of injury. The severity would vary based on individual fitness levels and adherence to safe exercise practices.

EXACT Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have finished my chemotherapy treatments.
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I am 18 years old or older.
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My colorectal cancer is confirmed and is at stage I, II, or III.
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I have had surgery to remove a tumor.
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I do not have any major surgeries planned during the study.
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I have finished any required radiotherapy.

EXACT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
High Sensitivity C-Reactive Protein
Interleukin-6
Secondary outcome measures
Circulating Tumor Cells
Insulin Resistance
Soluble Tumor Necrosis Factor-Alpha Receptor Two
Other outcome measures
Fatty Acid Oxidation
Mitochondrial Respiration Rate
Tumor Fraction

EXACT Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Aerobic ExerciseExperimental Treatment1 Intervention
Moderate-intensity aerobic exercise
Group II: ControlPlacebo Group1 Intervention
Wait-list control

Find a Location

Who is running the clinical trial?

Pennington Biomedical Research CenterLead Sponsor
304 Previous Clinical Trials
181,376 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,654 Previous Clinical Trials
40,933,093 Total Patients Enrolled
Justin C Brown, Ph.D.Principal InvestigatorPennington Biomedical Research Center

Media Library

Moderate-Intensity Aerobic Exercise Clinical Trial Eligibility Overview. Trial Name: NCT03975491 — N/A
Colorectal Cancer Research Study Groups: Aerobic Exercise, Control
Colorectal Cancer Clinical Trial 2023: Moderate-Intensity Aerobic Exercise Highlights & Side Effects. Trial Name: NCT03975491 — N/A
Moderate-Intensity Aerobic Exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT03975491 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the key goals of this clinical research?

"The primary goal of the trial, evaluated over a baseline period and 12 weeks, is to measure High Sensitivity C-Reactive Protein levels. Secondary objectives include evaluating Insulin Resistance through an Oral Glucose Tolerance Test (2 hour AUC), measuring Circulating Tumor Cells concentrations per mL in whole blood, and determining the proportion of Circulating Tumor DNA relative to all cell-free DNA (Tumor Fraction)."

Answered by AI

Does this clinical trial currently seek participants?

"According to the information uploaded on clinicaltrials.gov, this study is still open for enrolment. This medical experiment was first posted in August of 2019 and its details were amended as recently as February 2022."

Answered by AI

What is the enrolment size of this clinical research?

"Confirmed. Clinicaltrials.gov records show that this experiment, originally published on August 16th 2019, is looking for participants at present. The study requires 60 people to be recruited from 1 medical centre."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
The Exercise And Colorectal Cancer Treatment Trial
Justin Brown 2019. "The Exercise And Colorectal Cancer Treatment Trial". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03975491.
All > Colon Cancer
~11 spots leftby Apr 2025
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