Naltrexone and Bupropion for Binge Eating Disorder

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Yale Department of Psychiatry, New Haven, CTBinge Eating Disorder+1 MoreNaltrexone and Bupropion - Drug
Eligibility
18 - 64
All Sexes
What conditions do you have?
Select

Study Summary

This trial will compare the effectiveness of a combination of naltrexone and bupropion medication to placebo in patients with obesity who have not responded to other treatments for binge-eating disorder.

Eligible Conditions
  • Binge Eating Disorder
  • Obesity

Treatment Effectiveness

Study Objectives

2 Primary · 3 Secondary · Reporting Duration: From post-treatment to the 12-month follow-up

From post-treatment to the 12-month follow-up
Binge-Eating Frequency
Binge-Eating Remission
Body Mass Index
Depressive Symptoms
Eating-Disorder Psychopathology (Continuous)

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

2 Treatment Groups

Naltrexone/Bupropion
1 of 2
Placebo
1 of 2

Experimental Treatment

Non-Treatment Group

40 Total Participants · 2 Treatment Groups

Primary Treatment: Naltrexone and Bupropion · Has Placebo Group · Phase 2 & 3

Naltrexone/Bupropion
Drug
Experimental Group · 1 Intervention: Naltrexone and Bupropion · Intervention Types: Drug
Placebo
Other
PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: Other

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: from post-treatment to the 12-month follow-up

Who is running the clinical trial?

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH
2,186 Previous Clinical Trials
4,089,849 Total Patients Enrolled
Yale UniversityLead Sponsor
1,711 Previous Clinical Trials
20,477,987 Total Patients Enrolled
Carlos M Grilo, Ph.D.Principal InvestigatorYale School of Medicine
4 Previous Clinical Trials
422 Total Patients Enrolled

Eligibility Criteria

Age 18 - 64 · All Participants · 7 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You must be between 18 and 64 years of age.
You have been diagnosed with binge-eating disorder according to the DSM-5 criteria.

Frequently Asked Questions

What are the effects of Naltrexone and Bupropion?

"Naltrexone and Bupropion is an effective treatment for not just ADHD, but also other disorders such as SAD, smoking cessation, and smoke." - Anonymous Online Contributor

Unverified Answer

What are the ideal demographics for this clinical trial?

"This study is admitting 40 participants, between the ages of 18 and 64 who currently have binge-eating disorder. It is required that participants also meet the following criteria: BMI 27-30 with a controlled obesity-related co-morbidity; or BMI ≥ 30 and <50, Medically cleared as determined by EKG and medical record review, Able to travel to study location (New Haven, CT) for weekly visits, 18 to 64 years old, Available for the duration of the treatment and follow-up (18 months)." - Anonymous Online Contributor

Unverified Answer

The age limit for this research is _____ years old, correct?

"The age limit for this clinical trial is 64 years old. As long as participants are over 18 years old, they are eligible for the study." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.