12 Participants Needed

Beetroot Juice for Missed Period

AR
Overseen ByAndrew R Coggan, PhD

What You Need to Know Before You Apply

What is the purpose of this trial?

Excessive exercise, disordered attitudes toward eating, physical and psychological stress, and/or hormonal imbalances may result in cessation of menstruation (secondary amenorrhea). The accompanying lack of estrogen may impair muscle power and oxygen recovery after exercise by reducing nitric oxide levels. The purpose of this study is to determine whether ingestion of beetroot juice containing nitrate, an alternative source of nitric oxide, can help reverse these changes.

Who Is on the Research Team?

AR

Andrew R Coggan, PhD

Principal Investigator

Indiana University Indianapolis

Are You a Good Fit for This Trial?

This trial is for women experiencing missed periods due to excessive exercise, eating disorders, stress, or hormonal imbalances. Participants should be currently facing secondary amenorrhea and are interested in exploring the effects of dietary nitrate found in beetroot juice.

Inclusion Criteria

Missed >3 consecutive periods in the last 12 months if previously regularly menstruating (average cycle 21-35 d) OR missed >6 consecutive periods in the last 12 months if previously irregularly menstruating (spontaneous menstruation, average cycle <21 or >35 d)
I am a woman aged between 18 and 44.

Exclusion Criteria

Weight instability for the past 3 months
Current nicotine user
I have epilepsy.
See 12 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either nitrate-rich beetroot juice or nitrate-free beetroot juice

2-3 hours
Single visit for juice ingestion and monitoring

Follow-up

Participants are monitored for muscle function and plasma nitrate/nitrite levels after treatment

1-3 hours
Monitoring during and after treatment visit

What Are the Treatments Tested in This Trial?

Interventions

  • Beetroot Juice
Trial Overview The study investigates if drinking beetroot juice with nitrate can improve muscle power and oxygen recovery after exercise by boosting nitric oxide levels. Women will either receive the active beetroot juice or a placebo without nitrate to compare outcomes.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Placebo Group
Group I: NitrateExperimental Treatment1 Intervention
Group II: PlaceboPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Indiana University

Lead Sponsor

Trials
1,063
Recruited
1,182,000+
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