Losartan for Coarctation of the Aorta
(VALUE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.
Will I have to stop taking my current medications?
If you are currently taking beta blockers or have received any antihypertensive medications in the past year, you cannot participate in this trial. The protocol does not specify about other medications, so it's best to discuss with the trial team.
Is losartan safe for humans?
How does the drug Losartan differ from other treatments for coarctation of the aorta?
Losartan is unique because it targets the renin-angiotensin system, which is involved in blood pressure regulation, and may help manage hypertension (high blood pressure) associated with coarctation of the aorta. Unlike surgical options that directly address the physical narrowing of the aorta, Losartan offers a non-surgical approach by potentially reducing blood pressure through its action on angiotensin receptors.678910
Who Is on the Research Team?
Alexander Egbe, MBBS, MPH
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
This trial is for adults with a history of early childhood repair of coarctation of the aorta and slightly elevated blood pressure. They must not be on beta blockers, pregnant, or have severe kidney issues, high potassium levels, significant heart valve problems, coronary artery disease, or taken blood pressure meds in the last year.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either Losartan, Amlodipine, or Placebo for the treatment of coarctation of aorta
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Amlodipine
- Losartan
- Placebo
Losartan is already approved in United States, European Union, Canada for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator