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Smell training for Loss of Smell (OTTODC19 Trial)

N/A
Waitlist Available
Led By Johannes A Frasnelli, PhD
Research Sponsored by Université du Québec à Trois-Rivières
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up measurement will be taken at time zero (pre-intervention)
Awards & highlights

Summary

This trial will help assess if olfactory training can help improve olfactory function in patients with post-COVID olfactory dysfunction.

Eligible Conditions
  • Loss of Smell
  • COVID-19
  • Parosmia
  • Reduced Sense of Smell
  • Coronavirus

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~measurement will be taken at time zero (pre-intervention) and 12 weeks (post-intervention)
This trial's timeline: 3 weeks for screening, Varies for treatment, and measurement will be taken at time zero (pre-intervention) and 12 weeks (post-intervention) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Changes from baseline in olfactory score on the Sniffin's Sticks test
Changes from baseline in olfactory score on the University of Pennsylvania Identification Test (UPSIT) [ Time Frame: Measurement will be taken at time zero (pre-intervention) and 12 weeks (post-intervention)
Parosmia and phantosmia assessment test
+2 more
Secondary outcome measures
Nasal Obstruction Symptom Evaluation (NOSE)

Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: Chemosensory training group 2Experimental Treatment1 Intervention
For 12 weeks, morning and evening, smell four odors namely coffee aroma, cheese aroma, strawberries, and limon, for a total of five minutes per session.
Group II: Chemosensory training group 1Experimental Treatment1 Intervention
For 12 weeks, morning and evening, smell four odors namely eucalyptol, phenyl ethanol, Orange, and eugenol, for a total of five minutes per session.
Group III: Chemosensory training group 3Placebo Group1 Intervention
For 12 weeks, morning and evening, smell four same odorless substance.

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Who is running the clinical trial?

Université du Québec à Trois-RivièresLead Sponsor
47 Previous Clinical Trials
4,415 Total Patients Enrolled
Johannes A Frasnelli, PhDPrincipal InvestigatorUniversité du Québec à Trois-Rivières
~33 spots leftby Jul 2025