Study Summary
This trial is comparing two different treatments to see which is more effective in improving community functioning.
Eligible Conditions
- Schizophrenia
Treatment Effectiveness
Effectiveness Progress
Study Objectives
3 Primary · 16 Secondary · Reporting Duration: Measurement at 0, 6, 12, 18, 24 months
Month 24
Change in 9-Hole Pegboard Dexterity
Change in Auditory Verbal Learning Test
Change in Dimensional Change Card
Change in Flanker Inhibitory Control and Attention
Change in Heinrich Quality of Life Scale
Change in List Sorting Working Memory
Change in Managing Emotions
Change in Oral Digit Symbol Test (Speed of Processing)
Change in Oral Reading Recognition
Change in Pattern Comparison Processing Speed
Change in Penn Conditional Exclusion Test
Change in Penn Continuous Performance Test
Change in Penn Digit Symbol Test
Change in Penn Mouse Practice Test
Change in Picture Sequence Memory
Change in Picture Vocabulary
Change in Positive and Negative Syndrome Scale, PANSS-6
Change in Social Adjustment Scale II
Change in Social Skills Performance Assessment
Trial Safety
Safety Progress
Trial Design
2 Treatment Groups
Social Skills Training
1 of 2
Cognitive Enhancement Therapy
1 of 2
Active Control
Experimental Treatment
378 Total Participants · 2 Treatment Groups
Primary Treatment: Cognitive Enhancement Therapy · No Placebo Group · N/A
Cognitive Enhancement Therapy
Behavioral
Experimental Group · 1 Intervention: Cognitive Enhancement Therapy · Intervention Types: BehavioralSocial Skills Training
Behavioral
ActiveComparator Group · 1 Intervention: Social Skills Training · Intervention Types: BehavioralTreatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cognitive Enhancement Therapy
2012
N/A
~160
Trial Logistics
Trial Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: measurement at 0, 6, 12, 18, 24 months
Who is running the clinical trial?
Beth Israel Deaconess Medical CenterLead Sponsor
777 Previous Clinical Trials
844,002 Total Patients Enrolled
19 Trials studying Schizophrenia
1,310 Patients Enrolled for Schizophrenia
Patient-Centered Outcomes Research InstituteOTHER
493 Previous Clinical Trials
29,829,817 Total Patients Enrolled
4 Trials studying Schizophrenia
85,938 Patients Enrolled for Schizophrenia
Matcheri S Keshavan, MDPrincipal InvestigatorBeth Israel Deaconess Medical Center
1 Previous Clinical Trials
67 Total Patients Enrolled
1 Trials studying Schizophrenia
67 Patients Enrolled for Schizophrenia
Russell K Schutt, PhDPrincipal InvestigatorBeth Israel Deaconess Medical Center
Eligibility Criteria
Age 18 - 65 · All Participants · 3 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:References
- Schutt, Russell K., Haiyi Xie, Kim T. Mueser, Matthew A. Killam, Jonathan Delman, Shaun M. Eack, Raquelle Mesholam-Gately, et al.. 2022. “Cognitive Enhancement Therapy Vs Social Skills Training in Schizophrenia: A Cluster Randomized Comparative Effectiveness Evaluation”. BMC Psychiatry. Springer Science and Business Media LLC. doi:10.1186/s12888-022-04149-x.
- Schutt RK, Xie H, Mueser KT, Killam MA, Delman J, Eack SM, Mesholam-Gately R, Pratt SI, Sandoval L, Santos MM, Golden LR, Keshavan MS. Cognitive Enhancement Therapy vs social skills training in schizophrenia: a cluster randomized comparative effectiveness evaluation. BMC Psychiatry. 2022 Sep 1;22(1):583. doi: 10.1186/s12888-022-04149-x. Erratum in: BMC Psychiatry. 2022 Sep 16;22(1):613.
- Schutt RK, Xie H, Mueser KT, Killam MA, Delman J, Eack SM, Mesholam-Gately R, Pratt SI, Sandoval L, Santos MM, Golden LR, Keshavan MS. Cognitive Enhancement Therapy vs social skills training in schizophrenia: a cluster randomized comparative effectiveness evaluation. BMC Psychiatry. 2022 Sep 1;22(1):583. doi: 10.1186/s12888-022-04149-x. Erratum In: BMC Psychiatry. 2022 Sep 16;22(1):613.
- Matcheri S. Keshavan MD 2021. "Comparative Effectiveness of CET vs. SST in SMI (Serious Mental Illness)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04321759.
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Conditions
Cancer Related
Treatments