Topical Cream for Peripheral Neuropathy
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a skin cream called WST-057 on patients receiving chemotherapy with Carboplatin and Paclitaxel. The cream is applied to the skin to help manage side effects from the chemotherapy. Carboplatin and Paclitaxel are frequently used together in treatments for various cancers, including gynecological malignancies.
Will I have to stop taking my current medications?
The trial requires that you stop taking regular pain medications like gabapentin, pregabalin, amitriptyline, or duloxetine, unless they are opioids for short-term malignant pain. Also, you cannot use local anesthetics or analgesics like lidocaine or capsaicin.
Is the topical cream for peripheral neuropathy safe for humans?
How does the topical cream for peripheral neuropathy differ from other treatments?
What data supports the effectiveness of the drug Topical Pirenzepine for treating peripheral neuropathy?
Who Is on the Research Team?
Angela Hansen
Principal Investigator
WinSanTor, Inc
Are You a Good Fit for This Trial?
Adults over 18 with advanced solid tumors undergoing chemotherapy (carboplatin and paclitaxel) can join. They must be able to fill out questionnaires, have a life expectancy of at least 6 months, an ECOG status of 0-2, and use effective contraception. Excluded are those with pre-existing neuropathy not from chemo, certain health conditions or treatments that could interfere with the study.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive once-daily topical WST-057 or placebo for up to 19 weeks, or up to 24 weeks if there is a chemotherapy dose delay, alongside 6 cycles of Carboplatin and Paclitaxel
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Placebo
- Topical Pirenzepine
Find a Clinic Near You
Who Is Running the Clinical Trial?
WinSanTor, Inc
Lead Sponsor