Magnetic Seizure Therapy for Schizophrenia
(MAST Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to assess the clinical effects and tolerability of Magnetic Seizure Therapy (MST) as an alternative to electroconvulsive therapy (ECT) for Treatment Resistant Schizophrenia (RS).
Will I have to stop taking my current medications?
The trial requires that you keep your current antipsychotic treatment constant during the acute phase of the intervention. However, if you are taking a benzodiazepine at a dose higher than lorazepam 2 mg/day or any anticonvulsant, you may need to stop or adjust those medications.
Is Magnetic Seizure Therapy (MST) safe for humans?
Magnetic Seizure Therapy (MST) has been studied for schizophrenia and major depressive disorder, showing some side effects like dizziness and memory loss, but no serious adverse effects were consistently reported. It is considered to have fewer cognitive side effects compared to electroconvulsive therapy.12345
How is Magnetic Seizure Therapy different from other treatments for schizophrenia?
Magnetic Seizure Therapy (MST) is a new treatment that uses magnetic fields to induce seizures, similar to electroconvulsive therapy (ECT), but with more precise targeting and potentially fewer cognitive side effects. Unlike traditional antipsychotic medications, MST is a non-invasive brain stimulation technique, offering an alternative for patients who do not respond to standard drug treatments.13678
What data supports the effectiveness of the treatment Magnetic Seizure Therapy (MST) for schizophrenia?
Magnetic Seizure Therapy (MST) has shown potential as a treatment for schizophrenia, with some patients experiencing symptom improvements. In a small study, five out of eight patients showed a reduction in symptoms, and three achieved a significant clinical response. MST is also being explored for its benefits in treating major depressive disorder, suggesting it may have broader mental health applications.13489
Who Is on the Research Team?
Daniel Blumberger, MD
Principal Investigator
Centre for Addiction and Mental Health
Are You a Good Fit for This Trial?
This trial is for individuals with Treatment Resistant Schizophrenia, meaning their condition hasn't improved after trying other treatments. Participants should be able to undergo procedures like Magnetic Seizure Therapy (MST) or Electroconvulsive Therapy (ECT).Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive Magnetic Seizure Therapy (MST) or Electroconvulsive Therapy (ECT) two to three days per week. Treatment continues until response criteria are met or up to 15 sessions.
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Magnetic Seizure Therapy (MST)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Centre for Addiction and Mental Health
Lead Sponsor
University of British Columbia
Collaborator