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Antibiotic

Antibiotics for Cat Bite Injuries (CATBITE Trial)

Phase 4

Recruiting

Led By Kevin M Klifto, DO, PharmD

Research Sponsored by University of Missouri-Columbia

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up day 2; day 7+/-2; day 14+/-2; day 30+/-2

Awards & highlights

CATBITE Trial Summary

This trial investigates duration of prophylactic antibiotics & placebo control for cat bites to the hand/forearm to reduce incidence of infection.

Who is the study for?

Adults over 18 who've been bitten by a cat on the hand or forearm within the last 24 hours can join this trial. They must speak English and be willing to take medication and attend follow-ups. Excluded are those with active infections, recent antibiotic use, immunodeficiencies, certain chronic diseases, fever above 100.4°F, pregnancy, malnutrition or hypersensitivity to study drugs.Check my eligibility

What is being tested?

The CATBITE trial is testing if antibiotics prevent infection after a cat bite to the hand/forearm. Participants will randomly receive either a placebo; amoxicillin-clavulanate for one day; or amoxicillin-clavulanate for five days. The study will monitor infection development and assess disability and quality of life through questionnaires.See study design

What are the potential side effects?

Possible side effects from antibiotics may include digestive issues like diarrhea or nausea, allergic reactions such as rashes or itching, and rarely more serious effects like severe intestinal conditions (C.difficile) or anaphylaxis in case of allergy.

CATBITE Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ day 2; day 7+/-2; day 14+/-2; day 30+/-2

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~day 2; day 7+/-2; day 14+/-2; day 30+/-2

This trial's timeline: 3 weeks for screening, Varies for treatment, and day 2; day 7+/-2; day 14+/-2; day 30+/-2 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Changes of the incidence of infection

Incidence of infection

Secondary outcome measures

Adverse effects

Changes in HAND Questionnaire (HAND-Q) scores

Changes in Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH) scores

+3 more

Other outcome measures

Changes in location of cat bites that result in infection

Location of cat bites that result in infection

CATBITE Trial Design

3Treatment groups

Active Control

Placebo Group

Group I: Antibiotic x 1 dayActive Control5 Interventions

Amoxicillin-clavulanate 875-125mg capsules by mouth twice daily x 1 day (4 days of placebo capsules) -Penicillin allergy: ciprofloxacin 500mg by mouth twice daily + clindamycin 300mg by mouth three times daily x 1 day

Group II: Antibiotic x 5 daysActive Control4 Interventions

Amoxicillin-clavulanate 875-125mg capsules by mouth twice daily x 5 days (0 days of placebo capsules) -Penicillin allergy: ciprofloxacin 500mg by mouth twice daily + clindamycin 300mg by mouth three times daily x 5 days

Group III: Placebo (microcrystalline cellulose)Placebo Group2 Interventions

Placebo capsules by mouth twice daily x 5 days (5 days of placebo microcrystalline cellulose capsules)

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of Missouri-ColumbiaLead Sponsor

362 Previous Clinical Trials

628,042 Total Patients Enrolled

1 Trials studying Hand Injuries

6 Patients Enrolled for Hand Injuries

Kevin M Klifto, DO, PharmDPrincipal InvestigatorUniversity of Missouri-Columbia

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What potential hazardous effects might arise from taking Antibiotic x 1 day?

"There is ample evidence to suggest that Antibiotic x 1 day is highly efficacious, so it was assigned a score of 3."

Answered by AI

Are there still vacant positions for volunteers in this research?

"This clinical study is looking for participants, as reported on clinicaltrials.gov; the trial was initially published on September 7th 2023 and has been modified recently."

Answered by AI

How many individuals are actively engaged in this research?

"Affirmative, clinicaltrials.gov's records suggest that this trial is actively recruiting. This research was first launched on September 7th 2023 and has since been updated with the same date. 72 patients are sought from a singular medical centre."

Answered by AI

What is the ultimate objective of this investigative research?

"This trial will be evaluated over a Day 2; Day 7+/-2; Day 14+/-2; and Day 30+/-2 timeframe in order to measure the Incidence of infection. Secondary outcomes include HAND Questionnaire (HAND-Q) scores, which are calculated by summing up raw item scores into a total scale score that ranges from 0 (worst) to 100 (best). Additionally, changes in adverse effects across each study arm as well as Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH) scores measured on a scale of 0 to 100 will also be assessed."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

CAT BITE Antibiotic Prophylaxis for the Hand/Forearm (CATBITE)

Stephen Colbert 2023. "CAT BITE Antibiotic Prophylaxis for the Hand/Forearm (CATBITE)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05846399.

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