GAE and MRI treatment arm for Osteoarthritis, Knee

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Medical University of South Carolina, Charleston, SC
Osteoarthritis, Knee
geniculate artery embolization - Procedure
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

The objective of this study is to investigate if MRI can be used to evaluated effect of knee artery embolization for knee osteoarthritis. Participants be evaluated in clinic, obtain a knee MRI, undergo embolization of the symptomatic knee, and follow up in clinic at 1, 6, and 12 months after embolization. A second MRI is obtained 6 months after embolization. Participants will keep a record of their pain level and treatment and answer questionnaires at each visit. In addition, this study aims to determine the effects of knee artery embolization on the amount of opioid (pain reliever drugs) needed to manage osteoarthritis-associated pain and change in quality of life.

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Osteoarthritis, Knee

Study Objectives

5 Primary · 0 Secondary · Reporting Duration: 12 month post procedure

12 month post procedure
Incidence of adverse events associated with GAE
Month 12
Number of participants with 50% reduction in pain scores
Month 6
Change in Multicenter Osteoarthritis Study (MOST) grading system for synovitis
Change in Whole-Organ Magnetic Resonance Scoring (WORMS)
Change in enhancement time intensity curves obtained from CE-MRI

Trial Safety

Safety Progress

1 of 3

Other trials for Osteoarthritis, Knee

Trial Design

1 Treatment Group

GAE and MRI treatment arm
1 of 1
Experimental Treatment

12 Total Participants · 1 Treatment Group

Primary Treatment: GAE and MRI treatment arm · No Placebo Group · N/A

GAE and MRI treatment armExperimental Group · 2 Interventions: geniculate artery embolization, dynamic contrast enhanced MRI · Intervention Types: Procedure, DiagnosticTest

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 12 month post procedure

Trial Background

Prof. Andre Uflacker, MD
Principal Investigator
Medical University of South Carolina
Closest Location: Medical University of South Carolina · Charleston, SC
Photo of medical university of south carolina  1Photo of medical university of south carolina  2Photo of medical university of south carolina  3
1993First Recorded Clinical Trial
3 TrialsResearching Osteoarthritis, Knee
1223 CompletedClinical Trials

Eligibility Criteria

Age 18+ · All Participants · 5 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
Subjects must be able to provide informed consent.
Patients without contraindication to MRI imaging with gadolinium-based contrast.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.