Transcranial Magnetic Stimulation for Depression
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new approach to using Transcranial Magnetic Stimulation (TMS) for treating Major Depressive Disorder (MDD). Instead of spreading sessions over several weeks, participants will receive three sessions in one day, aiming to make treatment more convenient. This accelerated rTMS treatment seeks to determine if this shorter schedule is as safe and effective as the traditional method. Suitable candidates have MDD, haven't found relief from antidepressants, and are willing to keep their medications stable during the study. As an unphased trial, this study offers participants a unique opportunity to contribute to innovative research that could transform future treatment options.
Do I have to stop taking my current medications for the trial?
No, you don't have to stop taking your current medications. The trial requires participants to stay on stable medications during the therapy.
What prior data suggests that this accelerated rTMS treatment is safe for adults with MDD?
Research has shown that accelerated Transcranial Magnetic Stimulation (TMS) is safe and generally well-tolerated. One study found that 33% of patients responded positively after just one week, increasing to 43% by the fourth week. Another study discovered that using accelerated TMS with a special type of coil resulted in an 80% response rate and a 51% remission rate. This indicates that many patients experienced improvement or disappearance of their depression symptoms. These studies suggest that accelerated TMS is a promising and safe treatment for depression with fewer side effects.12345
Why are researchers excited about this trial?
Researchers are excited about this treatment because it offers a new protocol for Transcranial Magnetic Stimulation (TMS) that could significantly speed up depression relief. Unlike typical TMS treatments, which often require weeks of daily sessions, this accelerated rTMS treatment condenses the therapy into a single day with three sessions, each lasting 19 minutes, separated by 60-minute breaks. This rapid approach has the potential to provide quicker symptom relief, which is a game-changer for patients seeking faster improvements in their mental health.
What evidence suggests that this accelerated rTMS treatment is effective for depression?
Research has shown that accelerated Transcranial Magnetic Stimulation (TMS), which participants in this trial will receive, is a promising treatment for Major Depressive Disorder (MDD). One study found that 33% of participants responded positively after just one week, increasing to 43% by the fourth week. Another study reported a 47% reduction in depression symptoms by the third day of treatment. Accelerated TMS works faster and may be more effective than standard TMS. It is also considered safe and well-tolerated. Overall, accelerated TMS offers better results for people with depression compared to traditional methods.13456
Are You a Good Fit for This Trial?
Adults aged 22-85 with Major Depressive Disorder (MDD) can participate in this trial. The study is testing a new, accelerated TMS treatment schedule to see if it's as safe and effective as the standard regimen.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive three 19-minute rTMS treatment sessions in one day with 60 minutes rest between sessions
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Accelerated rTMS treatment
Find a Clinic Near You
Who Is Running the Clinical Trial?
NeuroQore Inc.
Lead Sponsor
Makromed Inc.
Collaborator