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PET Imaging for Neuropsychiatric Disorders

Phase 1
Recruiting
Led By Alan Prossin, MBBS
Research Sponsored by The University of Texas Health Science Center, Houston
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Must be between 18-80 years old
Must be able to sit unaccompanied for long periods of time with little body movement
Timeline
Screening 3 weeks
Treatment Varies
Follow Up obtained during pet scanning (between 1:30 pm and 3 pm) at study baseline within a few days of study enrollment
Awards & highlights

Study Summary

This trial will explore whether there is more inflammation in the brain of people with clinical evidence of neuropsychiatric syndromes.

Who is the study for?
This trial is for adults aged 18-45 who are right-handed and can sit still for long periods. It's open to healthy individuals or those with neuropsychiatric conditions like mood disorders, chronic pain, dementia, brain injuries, or substance abuse. Participants must not be pregnant, nursing, smokers, claustrophobic, drug users at the time of scanning (confirmed by a negative urine test), or have metal objects that could interfere with MRI.Check my eligibility
What is being tested?
The study aims to detect brain inflammation in people with neuropsychiatric syndromes using PET scans with radiotracers [11C]PBR-28 or [11C]ER176. Researchers want to see if there's more inflammation in patients showing stronger symptoms of these conditions.See study design
What are the potential side effects?
Potential side effects may include discomfort from sitting still during the PET scan and reactions related to the injection site of the radiotracer such as redness or swelling. There might also be rare allergic reactions to the tracer.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 80 years old.
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I can sit by myself for a long time without moving much.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~obtained during pet scanning (between 1:30 pm and 3 pm) at study baseline within a few days of study enrollment
This trial's timeline: 3 weeks for screening, Varies for treatment, and obtained during pet scanning (between 1:30 pm and 3 pm) at study baseline within a few days of study enrollment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Positron-Emission Tomography
Secondary outcome measures
Mental Depression
Affect as measured by the Positive and Negative Affect Schedule (PANAS)
Mental Status as measured by the Montreal Cognitive Assessment (MoCA)

Trial Design

2Treatment groups
Experimental Treatment
Group I: PET with radiotracer [11C]PBR-28 or [11C]ER176 and affective challengeExperimental Treatment2 Interventions
PET with radiotracer [11C]PBR-28 or [11C]ER176 will be performed. [11C]PBR-28 or [11C]ER176 will be injected into subjects' veins during PET scanning. Affective challenge (e.g. induction of mood, affective pain) will be presented to the patient during the PET scanning period.
Group II: PET with radiotracer [11C]PBR-28 or [11C]ER176Experimental Treatment1 Intervention
PET with radiotracer [11C]PBR-28 or [11C]ER176 will be performed. [11C]PBR-28 or [11C]ER176 will be injected into subjects' veins during PET scanning.

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

The University of Texas Health Science Center, HoustonLead Sponsor
902 Previous Clinical Trials
320,739 Total Patients Enrolled
Alan Prossin, MBBSPrincipal InvestigatorThe University of Texas Health Science Center, Houston

Media Library

PET with radiotracer [11C]PBR-28 ( or [11C]ER176) Clinical Trial Eligibility Overview. Trial Name: NCT03705715 — Phase 1
Neuropsychiatric Disorders Research Study Groups: PET with radiotracer [11C]PBR-28 or [11C]ER176, PET with radiotracer [11C]PBR-28 or [11C]ER176 and affective challenge
Neuropsychiatric Disorders Clinical Trial 2023: PET with radiotracer [11C]PBR-28 ( or [11C]ER176) Highlights & Side Effects. Trial Name: NCT03705715 — Phase 1
PET with radiotracer [11C]PBR-28 ( or [11C]ER176) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03705715 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has the Food and Drug Administration given its seal of approval to PET scans using [11C]PBR-28 or [11C]ER176?

"Our team at Power gave PET with radiotracer [11C]PBR-28 (or [11C]ER176) a score of 1 out of 3 as this is only in the initial testing phase, and there is limited data available on its safety or efficacy."

Answered by AI

Is there an opportunity to participate in this experiment?

"This medical investigation is taking on 200 individuals of ages 18 to 45 who have neuropsychiatric conditions. The eligibility criteria include being either healthy without any neurological or psychiatric illness, having a diagnosed neuropsychiatric syndrome such as mood disorder or substance/alcohol use disorder, and the ability to sit still for prolonged periods of time with minimal body movement (in case of control volunteers)."

Answered by AI

How many individuals are participating in the current research endeavor?

"Affirmative, the clinicaltrials.gov website attests that this research endeavor is actively seeking participants. Initially posted on May 1st 2017 and recently updated on September 27th 2021, it necessitates 200 volunteers from a single site for inclusion in the study."

Answered by AI

Is there still availability for people to participate in this research venture?

"Affirmative, the details highlighted on clinicaltrials.gov demonstrate this research is presently recruiting participants. The study was first published on May 1st 2017 and has been revised as recently as September 27th 2021; 200 candidates are required from a single medical centre."

Answered by AI

Does the research accept participants aged 18 and above?

"In line with the requirements for enrollment, prospective participants must be aged between 18 and 45."

Answered by AI

Who else is applying?

What state do they live in?
Texas
How old are they?
18 - 65
What site did they apply to?
BBSB at UTHealth
What portion of applicants met pre-screening criteria?
Met criteria
~77 spots leftby Aug 2028