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Whole-Body PET Scans for Multiple Sclerosis (EPSMS Trial)

Phase < 1
Recruiting
Led By Carl Taswell, MD, PhD
Research Sponsored by Brain Health Alliance
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Willing and able to lie motionless on the PET-CT scanner bed for at least 10 minutes and up to 20 minutes for the duration of the PET-CT medical imaging scan
Multiple sclerosis (MS) patients diagnosed by a credentialed neurologist experienced with care of multiple sclerosis patients
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 90 days
Awards & highlights

EPSMS Trial Summary

This trial will test whether a PET scanner can help improve the evaluation, monitoring and measurement of both peripheral and central demyelination in MS patients.

Who is the study for?
This trial is for individuals with Multiple Sclerosis diagnosed by a specialized neurologist, as well as healthy subjects. Participants must be able to stay still on the PET-CT scanner bed for 10-20 minutes. Those who've had recent surgery, cancer treatments, are pregnant or breastfeeding, have diabetes or other metabolic disorders, acute infections, or any serious illness besides MS cannot join.Check my eligibility
What is being tested?
The study is testing if whole-body PET scans using Amyvid radiopharmaceutical can better assess and monitor demyelination in MS patients. It aims to improve how we evaluate the spread and impact of MS throughout the body.See study design
What are the potential side effects?
Amyvid may cause side effects like headache, nausea, injection site pain or reactions. Since it's a radioactive drug used for imaging purposes, there's also a small risk associated with exposure to radiation during the PET scan.

EPSMS Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I can stay still on a scanner bed for up to 20 minutes.
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I have been diagnosed with MS by a specialist.

EPSMS Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 90 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 90 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Entire-body PET imaging of demyelination of peripheral and central nervous system
Psychometric questionnaire for monitoring psychological health

EPSMS Trial Design

2Treatment groups
Experimental Treatment
Group I: United Imaging uEXPLORER PET-CT scansExperimental Treatment2 Interventions
Parallel study arms defined by PET-CT scanners by different manufacturer and model
Group II: Siemens Biograph Vision PET-CT scansExperimental Treatment2 Interventions
Parallel study arms defined by PET-CT scanners by different manufacturer and model

Find a Location

Who is running the clinical trial?

Brain Health AllianceLead Sponsor
Carl Taswell, MD, PhDPrincipal InvestigatorBrain Health Alliance

Media Library

Entire-body PET-CT scans Clinical Trial Eligibility Overview. Trial Name: NCT04390009 — Phase < 1
Multiple Sclerosis Research Study Groups: United Imaging uEXPLORER PET-CT scans, Siemens Biograph Vision PET-CT scans
Multiple Sclerosis Clinical Trial 2023: Entire-body PET-CT scans Highlights & Side Effects. Trial Name: NCT04390009 — Phase < 1
Entire-body PET-CT scans 2023 Treatment Timeline for Medical Study. Trial Name: NCT04390009 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the qualifications for participating in this research project?

"To qualify for this particular trial, applicants need to have been diagnosed with multiple sclerosis and fall between the ages of 25-55. The research team is hoping to recruit 20 individuals in total."

Answered by AI

Does the enrollment criteria for this study include individuals over fifty years of age?

"With this analysis, patients within the age range of 25 to 55 are eligible for inclusion. Conversely, there are 44 trials that accept minors while 393 studies cater to seniors over 65 years old."

Answered by AI

What earlier studies have explored the therapeutic potential of this particular treatment?

"At this time, 3 clinical trials for the treatment are in progress. None of these have yet reached Phase 3. 8 medical centres across Ladera Ranch, California are testing the therapy in question."

Answered by AI

Is there still room for participants in this research trial?

"Affirmative. Per the information available on clinicaltrials.gov, this medical experiment is seeking participants and it was initially uploaded on September 1st 2022 with its latest amendment being published a day later. 20 subjects must be recruited from one particular trial site."

Answered by AI

What is the current enrollment capacity of this medical research project?

"Affirmative. Per the information found on clinicaltrials.gov, this experiment is presently seeking participants that were first posted about on September 1st 2022 and recently revised on September 2nd 2022. The study intends to recruit 20 individuals from a single research centre."

Answered by AI

Who else is applying?

What state do they live in?
California
What site did they apply to?
Brain Health Alliance
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
2
0

Why did patients apply to this trial?

How responsive is this trial?

Most responsive sites:
  1. Brain Health Alliance: < 48 hours
Average response time
  • < 2 Days
Typically responds via
Email
~0 spots leftby Apr 2024