Ketone Ester for Alcoholism
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this study is to learn more about how a nutritional supplement "ketone ester" (deltaG ®) has an effect on brain and heart function and on alcohol consumption in individuals with and without alcohol use disorder. The study will use Fluorodeoxyglucose (FDG) Positron Emission Tomography/Computed Tomography (PET/CT) scans after a single dose of ketone ester or Placebo in 10 people with alcohol use disorder and 10 healthy control volunteers.
Who Is on the Research Team?
Corinde E Wiers, Ph.D.
Principal Investigator
University of Pennsylvania
Are You a Good Fit for This Trial?
This trial is for adults aged 21-65, with or without alcohol use disorder, who can commit to the study and avoid alcohol for 24 hours before sessions. Excluded are those with seizures, high BMI (>35), metal implants incompatible with MRI/PET scans, vision issues not corrected by glasses, serious medical/psychological conditions, HIV positive individuals, pregnant/breastfeeding women, and certain psychiatric diagnoses.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
MRI Scan
Participants undergo an MRI scan to assess brain anatomy and function
PET/CT Scan with Ketone Ester
Participants receive a ketone ester drink and undergo a PET/CT scan to assess brain and heart function
PET/CT Scan without Ketone Ester
Participants undergo a PET/CT scan without the ketone ester to assess baseline brain and heart function
Follow-up
Participants are monitored for any side effects and changes in health after the study visits
What Are the Treatments Tested in This Trial?
Interventions
- FDG
- Ketone Ester (R)-3-hydroxybutyl (R)-3-hydroxybutyrate)
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Pennsylvania
Lead Sponsor