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FAZA PET Scan for Cervical Cancer
N/A
Waitlist Available
Led By Michael Milosevic, MD
Research Sponsored by University Health Network, Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
TNM (7th edition) cT1-4, N0-1, M0-1
Age ≥18 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights
Study Summary
This trial is testing whether a PET scan can show how much oxygen is in cervical cancer. Low oxygen levels may affect how well treatment works.
Who is the study for?
This trial is for adults with cervical cancer (squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma) who plan to undergo radiotherapy and possibly chemotherapy. They should not have had previous cancer treatment and must be able to lie down for PET scans. Pregnant women are excluded.Check my eligibility
What is being tested?
The study tests a special x-ray test called a PET scan using 18F-Fluoroazomycin Arabinoside (18F-FAZA) to detect low oxygen levels in cervical cancer tissue, which may affect the tumor's growth and treatment response.See study design
What are the potential side effects?
Since this trial involves diagnostic imaging rather than drug therapy, typical side effects associated with medications are not expected. However, there might be discomfort from lying still during the PET scan or reactions related to the contrast agent used.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
My cancer is in stages 1 to 4, may have spread to nearby lymph nodes, and might or might not have spread to distant parts of the body.
Select...
I am 18 years old or older.
Select...
I can sign and understand the consent form for this study.
Select...
I have not had chemotherapy for cervical cancer before joining this study.
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My cervical cancer is of a specific type (squamous, adenocarcinoma, or adenosquamous).
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 2 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Number of patients treated with the PET tracer FAZA to image primary tumor hypoxia in patients with cervix cancer prior to treatment with radiotherapy and concurrent cisplatin chemotherapy
Trial Design
1Treatment groups
Experimental Treatment
Group I: PET FAZA imagingExperimental Treatment1 Intervention
PET FAZA imaging of tumor hypoxia in patients with cervix cancer
Find a Location
Who is running the clinical trial?
University Health Network, TorontoLead Sponsor
1,476 Previous Clinical Trials
485,150 Total Patients Enrolled
Michael Milosevic, MDPrincipal InvestigatorPrincess Margaret Hospital, University Health Network
10 Previous Clinical Trials
1,118 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have had a complete or partial hysterectomy.I have cancer in the remaining part of my cervix after surgery.My cancer is in stages 1 to 4, may have spread to nearby lymph nodes, and might or might not have spread to distant parts of the body.I plan to undergo radiotherapy, possibly with cisplatin, for my condition as per PMH Gynecology Group's advice.I cannot lie on my back for more than 30 minutes.I am currently taking the medication Antabuse.I can sign and understand the consent form for this study.I am 18 years old or older.I have not had chemotherapy for cervical cancer before joining this study.Women of child-bearing age need to have a negative pregnancy test within two weeks before the PET-CT scan.My cervical cancer is of a specific type (squamous, adenocarcinoma, or adenosquamous).
Research Study Groups:
This trial has the following groups:- Group 1: PET FAZA imaging
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are any new participants being accepted to this experiment?
"According to the information hosted by clinicaltrials.gov, this particular study is no longer accepting applicants. Initially posted on May 1st 2011 and last adjusted October 21st 2022, the trial has fulfilled its recruitment needs; however 477 other trials are actively enrolling patients at present."
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