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Chronic Care for Smoking Cessation

Waitlist Available
Led By Michael Fiore, MD, MPH, MBA
Research Sponsored by University of Wisconsin, Madison
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Smoked cigarettes every day in the past 30 days (with or without other forms of tobacco or nicotine)
Be older than 18 years old
Must not have
Be younger than 18 years old
Screening 3 weeks
Treatment Varies
Follow Upup to 18 months
Awards & highlights
No Placebo-Only Group

Study Summary

This trial will compare a new healthcare approach, Comprehensive Chronic Care, with the Standard of Care, to see if it is more effective in helping smokers quit, reaches more people, and is more cost effective.

Eligible Conditions
  • Smoking Cessation

Eligibility Criteria

Inclusion Criteria

You will be eligible if you check “Yes” for the criteria below
You have smoked cigarettes every day in the last 30 days, with or without using other tobacco or nicotine products.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 18 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 18 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of Participants with biochemically confirmed point-prevalence abstinence at 18 months
Secondary outcome measures
Cost Effectiveness measured by incremental cost-effectiveness ratio (ICER)
Group differences in Cessation Treatment
Number of Participants with 7-day point-prevalence abstinence at 12 months
+2 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Comprehensive Chronic CareExperimental Treatment1 Intervention
ongoing proactive outreach designed to provide support and information about evidence-based smoking treatment, with access to individually validated treatments that are appropriate for patients who are: 1) unwilling quit but willing to reduce; 2) ready to quit; and 3) recovering from an unsuccessful quit attempt
Group II: Standard CareActive Control1 Intervention
involves one offer of cessation treatment (8 weeks of nicotine patch plus referral to the tobacco quit line), annually

Find a Location

Who is running the clinical trial?

University of Wisconsin, MadisonLead Sponsor
1,140 Previous Clinical Trials
2,945,043 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,486 Previous Clinical Trials
41,264,937 Total Patients Enrolled
Michael Fiore, MD, MPH, MBAPrincipal InvestigatorUW Center of Tobacco Research and Intervention
1 Previous Clinical Trials
14,930 Total Patients Enrolled

Media Library

Comprehensive Chronic Care Clinical Trial Eligibility Overview. Trial Name: NCT05382221 — N/A
Smoking Cessation Research Study Groups: Standard Care, Comprehensive Chronic Care
Smoking Cessation Clinical Trial 2023: Comprehensive Chronic Care Highlights & Side Effects. Trial Name: NCT05382221 — N/A
Comprehensive Chronic Care 2023 Treatment Timeline for Medical Study. Trial Name: NCT05382221 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Could you provide an update on the enrollment status of this clinical trial?

"Clinicaltrials.gov indicates that this medical trial which was initially posted on August 8th, 2022 is now closed for recruitment. Nevertheless, there are still 144 other trials open to new participants at the current time."

Answered by AI
~615 spots leftby Dec 2025