Study Summary
This trial will test whether training patients to increase their amygdala's response to positive memories can help treatment-resistant depression.
- Major Depressive Disorder
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 1 Secondary · Reporting Duration: 12 weeks
Trial Safety
Safety Progress
Trial Design
2 Treatment Groups
Parietal Neurofeedback
1 of 2
Amygdala Neurofeedback
1 of 2
Active Control
Experimental Treatment
100 Total Participants · 2 Treatment Groups
Primary Treatment: Amygdala Neurofeedback · No Placebo Group · N/A
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18 - 55 · All Participants · 6 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:- Young, Kymberly D., Greg J. Siegle, Vadim Zotev, Raquel Phillips, Masaya Misaki, Han Yuan, Wayne C. Drevets, and Jerzy Bodurka. 2017. “Randomized Clinical Trial of Real-time Fmri Amygdala Neurofeedback for Major Depressive Disorder: Effects on Symptoms and Autobiographical Memory Recall”. American Journal of Psychiatry. American Psychiatric Association Publishing. doi:10.1176/appi.ajp.2017.16060637.
- Young, Kymberly D., Greg J. Siegle, Vadim Zotev, Raquel Phillips, Masaya Misaki, Han Yuan, Wayne C. Drevets, and Jerzy Bodurka. 2017. “Randomized Clinical Trial of Real-time Fmri Amygdala Neurofeedback for Major Depressive Disorder: Effects on Symptoms and Autobiographical Memory Recall”. American Journal of Psychiatry. American Psychiatric Association Publishing. doi:10.1176/appi.ajp.2017.16060637.
- Kymberly Young 2018. "Neurofeedback for Treatment Resistant Depression". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03428828.
Frequently Asked Questions
What is the capacity of participants for this research trial?
"Affirmative. According to the clinicaltrials.gov records, this study is presently seeking individuals who meet its criteria for enrolment. This research was initially shared on October 22nd 2018 and was recently modified on December 2nd 2022. The trial aims to accept 100 participants at one medical centre." - Anonymous Online Contributor
Are new participants still able to join this research project?
"This trial is presently engaging participants. Initially posted on October 22nd 2018, the most recent edit to this clinical study occurred on December 2nd 2022 (as per information found on clinicaltrials.gov)." - Anonymous Online Contributor
Is the cutoff for enrollment into this medical trial set at 65 years old?
"This trial is only open to adults aged 18-55. Alternatively, there are 192 studies available for people below 18 years old and 969 trials targeting patients over 65." - Anonymous Online Contributor
Is my participation permissible in this research project?
"In order to be eligible for this clinical trial, individuals must have a diagnosis of depressive disorder and unresponsive to treatment. The age range is between 18-55 years old with around 100 enrollees being accepted." - Anonymous Online Contributor