Amygdala Neurofeedback for Major Depressive Disorder

Phase-Based Progress Estimates
University of Pittsburgh, Pittsburgh, PAMajor Depressive DisorderAmygdala Neurofeedback - Behavioral
18 - 55
All Sexes
What conditions do you have?

Study Summary

This trial will test whether training patients to increase their amygdala's response to positive memories can help treatment-resistant depression.

Eligible Conditions
  • Major Depressive Disorder

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 1 Secondary · Reporting Duration: 12 weeks

12 weeks
Beck Depression Inventory (BDI-II)
8 weeks
Amygdala Activity

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

Parietal Neurofeedback
1 of 2
Amygdala Neurofeedback
1 of 2

Active Control

Experimental Treatment

100 Total Participants · 2 Treatment Groups

Primary Treatment: Amygdala Neurofeedback · No Placebo Group · N/A

Amygdala Neurofeedback
Experimental Group · 1 Intervention: Amygdala Neurofeedback · Intervention Types: Behavioral
Parietal Neurofeedback
ActiveComparator Group · 1 Intervention: Parietal Neurofeedback · Intervention Types: Behavioral

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: 2 Weeks
Reporting: 3 Months

Who is running the clinical trial?

University of PittsburghLead Sponsor
1,634 Previous Clinical Trials
16,307,434 Total Patients Enrolled
Kymberly Young, PhDPrincipal Investigator - University of Pittsburgh
University of Pittsburgh
1 Previous Clinical Trials
200 Total Patients Enrolled

Eligibility Criteria

Age 18 - 55 · All Participants · 6 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
Only right-handed adults between 18 and 55 years old with recurrent major depressive disorder (MDD) based on DSM-5 diagnostic criteria will be selected. They must also be currently experiencing symptoms of depression.

Frequently Asked Questions

What is the capacity of participants for this research trial?

"Affirmative. According to the records, this study is presently seeking individuals who meet its criteria for enrolment. This research was initially shared on October 22nd 2018 and was recently modified on December 2nd 2022. The trial aims to accept 100 participants at one medical centre." - Anonymous Online Contributor

Unverified Answer

Are new participants still able to join this research project?

"This trial is presently engaging participants. Initially posted on October 22nd 2018, the most recent edit to this clinical study occurred on December 2nd 2022 (as per information found on" - Anonymous Online Contributor

Unverified Answer

Is the cutoff for enrollment into this medical trial set at 65 years old?

"This trial is only open to adults aged 18-55. Alternatively, there are 192 studies available for people below 18 years old and 969 trials targeting patients over 65." - Anonymous Online Contributor

Unverified Answer

Is my participation permissible in this research project?

"In order to be eligible for this clinical trial, individuals must have a diagnosis of depressive disorder and unresponsive to treatment. The age range is between 18-55 years old with around 100 enrollees being accepted." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.