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tACS for Aphasia After Stroke
N/A
Recruiting
Research Sponsored by Medical College of Wisconsin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Diagnosed with left hemisphere stroke/aphasia
18 years of age or older
Timeline
Screening 3 weeks
Treatment Varies
Follow Up upon the completion of therapy cycle (a cycle consists of 10 intervention days) and 10 weeks post
Awards & highlights
Study Summary
This trial looks at how electrical stimulation to the brain can help stroke survivors regain language abilities.
Who is the study for?
This trial is for English-speaking adults over 18 who have had a stroke affecting the left side of their brain, leading to aphasia. They must be at least one month post-stroke. People with severe sensory impairments, untreated psychiatric diseases, unstable medical conditions, pacemakers or cardiac stimulators, seizure disorders, dyslexia or learning disabilities cannot participate.Check my eligibility
What is being tested?
The study is testing whether transcranial alternating current stimulation (tACS), a non-invasive brain stimulation technique, can help improve short-term memory for words in people who have language difficulties after a stroke. Some participants will receive real tACS while others get sham (fake) treatment as a comparison.See study design
What are the potential side effects?
Possible side effects from tACS may include mild headaches, tingling on the scalp where electrodes are placed, fatigue shortly after treatment sessions and in rare cases light-headedness or nausea.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I had a stroke that affected the left side of my brain.
Select...
I am 18 years old or older.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ upon the completion of therapy cycle (a cycle consists of 10 intervention days) and 10 weeks post
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~upon the completion of therapy cycle (a cycle consists of 10 intervention days) and 10 weeks post
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Accuracy on a phonological STM task
fMRI measures of language network activation after tACS
Secondary outcome measures
Functional Communication Outcome
Trial Design
2Treatment groups
Experimental Treatment
Placebo Group
Group I: High Definition tACS with Short-term Memory Focused Speech TherapyExperimental Treatment1 Intervention
High-Definition-tACS will be delivered via a battery operated alternating current stimulator (Soterix) using two 3x1 center-surround montages.The current is turned on and increased in a ramplike fashion over approximately 30 seconds. Participants will undergo tACS stimulation for 20-minutes with 2 milliampere (mA) peak-to-peak intensity. Stimulation will be maintained no longer than 20 minutes. This will be paired with short-term memory focused speech therapy.
Group II: Sham-High Definition tACS with Short-term Memory Focused Speech TherapyPlacebo Group1 Intervention
High-Definition-tACS will be delivered via a battery operated alternating current stimulator (Soterix) using two 3x1 center-surround montages. The current is turned on and increased in a ramplike fashion for 10 to 30 seconds and then ramped down. In this way, the participants experience the same initial sensations (mild tingling) as the active tACS groups. This will be paired with short-term memory focused speech therapy.
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Who is running the clinical trial?
Medical College of WisconsinLead Sponsor
610 Previous Clinical Trials
1,162,593 Total Patients Enrolled
17 Trials studying Stroke
1,310 Patients Enrolled for Stroke
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is it still possible to enrol in this investigation?
"Affirmative, the details found on clinicaltrials.gov demonstrate that this trial is actively seeking out participants. Originally posted on September 1st 2023, it was most recently updated on September 15th of the same year and has a target of 120 patients from one site."
Answered by AI
How many participants are currently involved in this research study?
"Affirmative, according to clinicaltrials.gov the research is actively recruiting participants, with a begin date of September 1st 2023 and an update on September 15th 2023. The trial needs 120 volunteers across one location."
Answered by AI
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