PSMA-PET + MRI for Prostate Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is comparing two groups of patients undergoing surgery. One group will receive the usual imaging scan, while the other group will get an additional special scan that uses a dye to make cancer cells more visible. This new imaging method may help doctors plan surgeries better and improve patient outcomes.
Do I need to stop my current medications for the trial?
The trial protocol does not specify whether you need to stop taking your current medications.
Is PSMA-PET + MRI safe for use in humans?
How is the PSMA-PET + MRI treatment different from other prostate cancer treatments?
The PSMA-PET + MRI treatment is unique because it combines advanced imaging techniques to better detect and stage prostate cancer. This approach uses a special imaging agent, 68Ga-PSMA-11, which targets prostate-specific membrane antigen (PSMA) to provide more accurate and detailed images than traditional methods, helping to identify cancer spread more effectively.678910
What data supports the effectiveness of the treatment PSMA-PET + MRI for prostate cancer?
Who Is on the Research Team?
Clinton Bahler, MD
Principal Investigator
Indiana University School of Medicine
Are You a Good Fit for This Trial?
Men with significant prostate cancer planning to undergo surgery can join. They should have a certain level of prostate cancer severity, based on Gleason scores, and wish to maintain erections post-treatment. Men with any serious health issues, participating in other radiation trials recently, or unable to stay still for imaging due to physical limits or claustrophobia cannot participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Pre-surgical Imaging
Participants undergo standard of care MRI and possibly PSMA PET scan prior to surgery
Surgery
Participants undergo prostatectomy surgery with surgical plans potentially influenced by imaging findings
Follow-up
Participants are monitored for safety and effectiveness after surgery, including assessments of incontinence, erectile function, and overall health
What Are the Treatments Tested in This Trial?
Interventions
- PSMA-PET and SOC MRI
- SOC MRI
PSMA-PET and SOC MRI is already approved in United States, European Union for the following indications:
- Detection of prostate cancer spread
- Staging of prostate cancer
- Localization of recurrent prostate cancer
- Initial staging of prostate cancer
- Localization of recurrent prostate cancer
- Staging before PSMA-directed radioligand therapy
Find a Clinic Near You
Who Is Running the Clinical Trial?
Five Eleven Pharma, Inc.
Lead Sponsor
Indiana University
Collaborator