Lifestyle Changes for Healthy Aging

Overseen By Annie Kuan

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of British Columbia

Disqualifiers: Neurological disease, Cognitive impairment, Cardiovascular disease, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

60 Participants Needed

Trial Summary

What is the purpose of this trial?

The Impact 360 study will evaluate the effects of a combined intervention of exercise, mindfulness, and nutrition on 8 key indicators of health and the mechanisms that drive these changes. 60 subjects aged 50 to 75 without a current diagnosis of a brain disorder will be recruited. This study will follow a partial crossover design. All participants will receive the intervention. Participants randomized into the intervention group after their baseline screening will receive the 6-month intervention. Those randomized into the waitlist group will complete another assessment at the end of the 6-month care as usual phase before receiving the intervention.

Research Team

Silke Appel-Cresswell, MD, FRCPC

Principal Investigator

University of British Colombia

Eligibility Criteria

The Impact 360 study is for individuals aged between 50 to 75 who are generally healthy and do not have any brain disorders. Participants will be involved in activities aimed at promoting healthy aging.

Inclusion Criteria

Participants who are able to complete questionnaires and follow directions for interventions

Have access to a smartphone that can support the Fitbit app

Exclusion Criteria

Any chronic medical condition which would affect ability to participate in exercise

Any contraindication for exercise based on the Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) and medical clearance form

I exercise over 180 minutes weekly and practice mindfulness or follow the MIND diet.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Waitlist

Participants in the waitlist group undergo a baseline assessment and continue daily activities for 6 months with monitoring

6 months

Monthly virtual check-ins

Intervention

Participants receive a 6-month multimodal intervention including exercise, mindfulness, and nutrition

6 months

Regular assessments pre- and post-intervention

Follow-up

Participants are monitored for safety and effectiveness after the intervention

4 weeks

Treatment Details

Interventions

• Impact 360

Trial Overview This trial tests the combined effect of a regimen including exercise, diet changes, and meditation on health indicators in older adults. It uses a partial crossover design where all participants eventually receive the intervention after initial or delayed phases.

Participant Groups

Group I: Exercise, Diet, Mindfulness Experimental Treatment 3 Interventions

The intervention group will start the intervention immediately following their baseline assessment. They will undergo another assessment after the 6 month intervention period.

Group II: Waitlist Group Active Control 1 Intervention

Participants randomized into the waitlist group will undergo a baseline assessment, and will then be encouraged to continue their daily activities as usual for 6 months. Physical activity and sleep will be monitored during this time using wearable devices. Links to questionnaires will be emailed monthly. After the 6-month waitlist period, participants will undergo a second assessment prior to starting the intervention. The multimodal intervention will be 6-months in length, using the same measures of adherence, and will be followed by a final assessment.

Who Is Running the Clinical Trial?

University of British Columbia

Lead Sponsor

Trials

1,506

Recruited

2,528,000+

The Jack and Darlene Poole Foundation

Collaborator

Trials

1

Recruited

60+