This trial is evaluating whether IcoSema will improve 1 primary outcome and 10 secondary outcomes in patients with Diabetes Mellitus, Type 2. Measurement will happen over the course of From baseline week 0 (V2) to week 52 (V54).
This trial requires 680 total participants across 2 different treatment groups
This trial involves 2 different treatments. IcoSema is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 3 and have had some early promising results.
"Diabetes mellitus, type 2 (diabetes mellitus, type 2) is thought to involve multiple causes, including an increased susceptibility to beta-cell failure and an excess of beta-cell destruction. Other factors that could contribute to deterioration of islet function and increase risk for diabetes mellitus, type 2 include insulin resistance and alterations in the composition of the gut microbiome. Diabetes mellitus, type 2 can also be associated with an increased risk of atherosclerosis, hypercholesterolemia, and impaired microvascular blood flow.\nPatients who develop diabetes will likely need to follow a special dietary plan (diet). Dietary counseling will guide individuals to make changes in food choices and caloric intake." - Anonymous Online Contributor
"Diabetes is a metabolic disease characterized by insulin resistance, hyperglycemia, and a tendency toward dyslipidemia. Diabetes is a global epidemic that is expected to increase dramatically with lifestyle changes and increase with greater population growth. In the USA, there were approximately 7 million new cases of diabetes annually. type 2 diabetes mellitus is the most common type of diabetes mellitus." - Anonymous Online Contributor
"Although medication therapy is effective for correcting metabolic imbalances, many patients cannot maintain adequate glucose parameters and require frequent follow-up. The major problem in diabetes mellitus, type 2, treatment is the development of cardiovascular complications. Many physicians will focus on the control of hyperglycemia, but in many cases it is insufficient. In addition, treatment of this disease should include the prevention and control of hypertension and, in diabetic renal failure, lipid-based therapies. In summary, we must be aware of the importance of not only metabolic control but also of cardiovascular issues." - Anonymous Online Contributor
"There are a number of reasons why patients of any age and sex are encouraged to be screened for diabetes mellitus, type 2. Although the absolute risk of developing diabetes in those with undiagnosed diabetes is small, it is reasonable for them to pay careful attention to their diet and exercise habits. Screening for risk factors is also of immense importance. Therefore, the American Diabetes Association and Diabetes in Canada recommend that all adults be screened for the condition on an annual basis. Screening for diabetes is more effective, cheaper, and certainly more convenient when it is performed with a quick and accurate test such as fasting plasma glucose. Even after it is identified, a medical treatment can sometimes prevent this disease." - Anonymous Online Contributor
"Despite advances in treatment options for other diseases and conditions, a cure for diabetes mellitus, type 2 has yet to be discovered. However, this is not to say that the disease can not be controlled to the point where it can improve health and quality of life. While the precise benefits and risks of the different treatment options available must be weighed, a clear and balanced evaluation provides the best basis for guiding care." - Anonymous Online Contributor
"Approximately 8% of US men are diagnosed with type 2 diabetes. Type 2 diabetes screening in men in the population over the age of 65 is highly recommended to detect and to prevent this condition." - Anonymous Online Contributor
"Contrary to the expectation of increased familiality of diabetes in Type 2 diabetes, this study does not provide evidence for increased familiality of diabetes in Type 2 diabetes. More investigations are necessary to explain why family-wise risk is not elevated in Type 2 diabetes." - Anonymous Online Contributor
"There are no data specifically regarding icosema. The following applies to other diseases. One trial found no clinical significance between icosema and the placebo group in regards to the outcome measures. However, it found that icosema decreased the number of new lesions on the brain in the subjects who were treated with the drug compared to the untreated group. Studies with other pathogens, medications and drugs, other diseases, and also for different types of lesions should be carried out as a comparative study with icosema may give a better understanding of its role and impact." - Anonymous Online Contributor
"Results from a recent paper sample, the average age of the development of diabetes mellitus type 2 in patients younger than 64 years was 54.0 years, compared with 51.0 years in patients older than 64." - Anonymous Online Contributor
"While there is no doubt that the use of icosema led to increased A1c levels compared to the placebo group, these results showed that icosema did not differ from the placebo group in the clinical presentation of DM." - Anonymous Online Contributor
"The majority of diabetes therapies have involved oral or injectable agents, though there have also been some recent new discoveries including those that affect the brain. This article discusses some of the more common recent discoveries that have come forward." - Anonymous Online Contributor
"Patients will present with many possible symptoms and many tests and examinations are required for diagnosis before starting treatment. The initial treatment usually focuses on relieving symptoms of patients to help them live the full term of their life in comfort before receiving further treatment. Many symptoms are very common with patients suffering from IC, making it one that requires many treatments. A doctor's assessment of all possible symptoms are usually followed by a consultation with a nurse who will give advice and prescribe treatments to help the IC disease run its own course. As an alternative to regular checks, a nurse can also measure blood glucose levels regularly to see if patients have improved." - Anonymous Online Contributor