CLINICAL TRIAL

Treatment for Hemorrhage

Recruiting · 18+ · All Sexes · Chapel Hill, NC

Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

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About the trial for Hemorrhage

Eligible Conditions
Hemorrhage · Cerebral Hemorrhage · Atrial Fibrillation

Treatment Groups

This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 3 and have had some early promising results.

Control Group 1
Apixaban
DRUG
Control Group 2
Aspirin
DRUG

Eligibility

This trial is for patients born any sex aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Can be randomized within 14-180 days after ICH onset
Age at least 18 years
Intracerebral hemorrhage (ICH) (including primary intraventricular hemorrhage) confirmed by brain CT or MRI
Non-valvular AF (defined as atrial fibrillation or atrial flutter), documented by electrocardiography or a physician-confirmed history of prior AF
CHA2DS2-VASc score ≥ 2
Provision of signed and dated informed consent form by patient or legally authorized representative
For females of reproductive potential: use of highly effective contraception
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Up to 3 years
Screening: ~3 weeks
Treatment: Varies
Reporting: Up to 3 years
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Up to 3 years.
View detailed reporting requirements
Trial Expert
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- What options you have available- The pros & cons of this trial
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Measurement Requirements

This trial is evaluating whether Treatment will improve 1 primary outcome and 1 secondary outcome in patients with Hemorrhage. Measurement will happen over the course of Change from baseline to 12 months; change over duration of follow-up.

Modified Rankin Scale (mRS) score
CHANGE FROM BASELINE TO 12 MONTHS; CHANGE OVER DURATION OF FOLLOW-UP
Measure of neurologic disability (0=no disability to 6=dead)
CHANGE FROM BASELINE TO 12 MONTHS; CHANGE OVER DURATION OF FOLLOW-UP
Stroke or death
UP TO 3 YEARS
Incidence of stroke of any type (ischemic or hemorrhagic) or death from any cause
UP TO 3 YEARS

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the signs of hemorrhage?

Blood loss of more than 10 mL /kg/hr is considered clinically significant. Sudden loss of consciousness or dizziness is a worrying sign of severe blood loss.\n

Anonymous Patient Answer

Can hemorrhage be cured?

Hemorrhage is very dangerous to the patient, and the disease is very unlikely to be cured, and for ethical reasons it is not ethical to attempt to cure hemorrhage.

Anonymous Patient Answer

What are common treatments for hemorrhage?

There are a variety of therapies available for both external and internal hemorrhage. The most effective medications include corticosteroids for moderate to severe hemorrhaging, anticoagulants for acute stroke, vasoconstrictors in hypotensive hemorrhaging, antibiotics for infectious hemorrhages (bacterial or fungal), and blood products for life-threatening hemorrhages. The optimal length of time of treatment has yet to be determined.

Anonymous Patient Answer

What causes hemorrhage?

Hemorrhage can be caused by injuries, such as trauma or hemorrhagic heart disease. Trauma can be defined as an injury to the body that is of short duration. Typically a trauma patient should have a CT scan of the head to rule out any underlying head injuries before leaving the emergency room. Hemorrhagic heart diseases can be a consequence of an unstable heart, such as a heart attack or stroke. Treatment, which may include fibrinolysis and blood transfusions if the heart is not being adequately perfused, is recommended. Drugs, such as aspirin, can be used to help manage heart blood flow problems in these patients.

Anonymous Patient Answer

How many people get hemorrhage a year in the United States?

About 200,000 Americans have a hemorrhage each year. The most common causes are injury or illness, followed by pregnancy, traffic accidents, pregnancy, and pregnancy-related hemorrhage (especially miscarriage). In women, complications of pregnancy and childbirth cause about one fourth of all bleeding incidents, and hemorrhage tends to occur more frequently with advancing age. Bleeding may be serious because blood loss can lead to hypovolemia and hypotension. It may also be the first signs of a tumor or other underlying disease. Prevention and treatment may result in significant cost savings. Efforts to prevent and treat hemorrhage are needed to reduce morbidity and mortality, as indicated by the number of hospital days, emergency visits, and readmission rates.

Anonymous Patient Answer

What is hemorrhage?

Hemorrhagic disorders are a group of life-threatening illnesses in which blood loss is an important factor. Major contributors to hemorrhagic illnesses include trauma, childbirth and trauma. Hemorrhagic disorders should be determined rapidly in order to offer resuscitation.\n

Anonymous Patient Answer

What is the latest research for hemorrhage?

This article contains no new discoveries, but provides up-to-date evidence that has been discovered in the recent studies. Therefore, the most recent evidence for hemorrhage can be found by using [Rheology] and [Intravasculature hemorrhage]] software on PowerSurge and PowerSurge Plus devices. These devices are [incompatible with Powerlink] and [not compatible with Powerlink (see section Powerlink in the article Powerlink for information on Powerlink)).[https://www.withpower.com/rheology/power-surge-power-surge-plus].

Anonymous Patient Answer

What is treatment?

It is important to understand that not all patients will benefit from any treatment. Some treatment is required but only to relieve symptoms. You should look for information about the cost of a treatment, the risks, and any benefits. You may also look at the treatments suggested by your doctor based on your condition. You should consult a professional, such as a dietician or physio, when discussing your eating habits and exercise. If your symptoms continue, then you may benefit from a referral to your doctor, who will investigate your blood tests, blood pressure, and weight. If your symptoms continue or worsen, then you may be referred to an oncologist, preferably one in a hospital with access to modern treatment.

Anonymous Patient Answer

Have there been other clinical trials involving treatment?

There were no other studies to identify the treatment we used at the time of our patients. However, we anticipate that future clinical trials will use our treatment approach since our results compare favorably with a large number of studies published in the literature.

Anonymous Patient Answer

Is treatment typically used in combination with any other treatments?

There was limited adherence to standard treatment guidelines for hemorrhagic cysts, with a high degree of variability among specialists. Most patients responded to standard regimen of surgical intervention, and then retreated for symptomatic relapse. Further research is needed to identify which regimen best treats and prevents recurrent hemorrhagic cysts, while minimizing adverse effects.

Anonymous Patient Answer

What is the primary cause of hemorrhage?

Of all acute bleeding in the UK, about 15% of cases are not due to intentional self-harm (non-exsanguinations) and are therefore due to (pre-existing and undetected) underlying organic disease. The proportion of cases due to organic disease rises with rising age, but even after adjustment for this effect is similar to that for the rate in the general population and therefore is largely independent of age.

Anonymous Patient Answer

How serious can hemorrhage be?

As predicted, hemorrhage is devastating with devastating consequences. With a little bit of patience, however, hematic complications can respond to surgical intervention with a high rate of survival.

Anonymous Patient Answer
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