We started Power when my dad was diagnosed with multiple myeloma, and I struggled to help him access the latest immunotherapy. Hopefully Power makes it simpler for you to explore promising new treatments, during what is probably a difficult time.
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"I've tried several different SSRIs over the past 23 years with no luck. Some of these new treatments seem interesting... haven't tried anything like them before. I really hope that one could work."
"I changed my diet in 2020 and I’ve lost 95 pounds from my highest weight (283). I am 5’3”, female, and now 188. I still have a 33 BMI. I've been doing research on alternative approaches to continue my progress, which brought me here to consider clinical trials."
"My orthopedist recommended a half replacement of my right knee. I have had both hips replaced. Currently have arthritis in knee, shoulder, and thumb. I want to avoid surgery, and I'm open-minded about trying a trial before using surgery as a last resort."
"I've been struggling with ADHD and anxiety since I was 9 years old. I'm currently 30. I really don't like how numb the medications make me feel. And especially now, that I've lost my grandma and my aunt 8 days apart, my anxiety has been even worse. So I'm trying to find something new."
"As a healthy volunteer, I like to participate in as many trials as I'm able to. It's a good way to help research and earn money."
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6000 Participants Needed
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Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range for Phase 2–4 trials (Phase 1 trials often pay substantially more). Further, most trials will cover the costs of a travel to-and-from the clinic.
After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll be sorted into one of the treatment groups, and receive your study drug. For some trials, there is a chance you'll receive a placebo. Across Epilepsy trials 30% of clinical trials have a placebo. Typically, you'll be required to check-in with the clinic every month or so. The average trial length for Epilepsy is 12 months.
Not all studies recruit healthy volunteers: usually, Phase 1 studies do. Participating as a healthy volunteer means you will go to a research facility several times over a few days or weeks to receive a dose of either the test treatment or a "placebo," which is a harmless substance that helps researchers compare results. You will have routine tests during these visits, and you'll be compensated for your time and travel, with the number of appointments and details varying by study.
The phase of a trial reveals what stage the drug is in to get approval for a specific condition. Phase 1 trials are the trials to collect safety data in humans. Phase 2 trials are those where the drug has some data showing safety in humans, but where further human data is needed on drug effectiveness. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. As a general rule, Phase 3 trials are more promising than Phase 2, and Phase 2 trials are more promising than phase 1.
Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.
Most recently, we added Subcortical Arousal Study for Epilepsy, Zorevunersen for Dravet Syndrome and AGB101 for Dementia to the Power online platform.
Treatment usually starts with daily anti-seizure medicines—over 20 are available—and about two-thirds of people become seizure-free after trying one or two of them. If seizures continue, specialists can offer individualized next steps such as surgery to remove the seizure focus, implantable stimulators that “pace” the nerves or brain (VNS, RNS, deep-brain stimulation), dietary therapy like the ketogenic or modified Atkins diet, or newer drugs including purified cannabidiol. The best plan depends on seizure type, age, other health issues and personal preferences, so care is built in partnership with an epilepsy team.
Epilepsy can start two ways: you might be born with an underlying change in the brain — for example a genetic mutation or a problem that occurred during pregnancy or birth — or you can develop it later after things like a head injury, stroke, tumour or serious brain infection. Roughly one-third of cases are clearly “present from birth,” another third are due to later brain injuries or illnesses, and the rest have no obvious cause yet. In short, some people are born with the tendency, but anyone can develop epilepsy at any age if new damage or disease affects the brain’s electrical circuits.
The ILAE’s “Rule of 3” says you can call someone seizure-free when they have gone at least three times as long as their single longest gap between seizures before the new treatment—and in any case at least 12 months—without another event. For example, if the longest break before treatment was 2 months, you need 6 months but because the rule also sets a 12-month minimum you would actually wait a full year; if the longest break was 8 months, you would need 24 months seizure-free. This personalised yard-stick helps doctors judge whether an intervention is truly working and avoids declaring success either too early (for people who naturally had long intervals) or too late (for those who seized frequently).
The most immediately life-threatening situation is status epilepticus—any seizure that lasts five minutes or more or comes back before the person regains awareness; if this happens, give any prescribed rescue medicine and call emergency services because every extra minute increases the risk of brain injury or death. Over the long term, rare drug-resistant childhood syndromes such as Dravet or Lennox-Gastaut are often labeled the “most serious” because they cause daily seizures, developmental problems, and a higher risk of sudden death, so they require care at a specialized epilepsy center and a written emergency plan.
About two-thirds of children and roughly 60 % of adults who are just starting treatment become seizure-free long-term with medication alone. If seizures continue after trying two suitable drugs, the chance they stop on their own is small (under 5 % per year), but surgery or other specialised treatments can lift the seizure-free rate to about 50-70 % in people who are good candidates. Your exact odds depend on the epilepsy type, brain scans and early response to medicine, so work with your neurologist before deciding whether to stay on, stop, or escalate treatment.
No single food can guarantee seizure prevention. What has solid evidence is a medically supervised, high-fat/very-low-carb diet (classic ketogenic or its easier cousins, the modified Atkins and low-glycaemic-index plans), which can reduce seizure frequency in about half of patients and make some seizure-free. If you’re not on one of these programs, aim for steady blood-sugar meals—plenty of non-starchy vegetables, healthy fats (olive oil, avocado, nuts, fatty fish), regular protein, and minimal added sugar—and talk with your neurologist or a dietitian before making major changes.
People with epilepsy usually face two overlapping hurdles: the seizures themselves—figuring out triggers, preventing injuries, and coping with restrictions on driving, work, or sports—and the wider “after-shocks,” such as memory lapses, mood problems, medication side-effects, stigma, and added financial or school stress. Pinpointing which of these areas is causing the most strain and partnering with a neurologist on medication adherence, mental-health care, safety planning, and community support can greatly reduce risk and help regain independence.
Think of a seizure as a one-time electrical “short-circuit” in the brain that can be set off by things like fever, low blood sugar, or head injury; once the trigger is gone, the risk may disappear. Epilepsy is the medical disorder in which the brain itself has an ongoing tendency to seize—diagnosed when someone has at least two unprovoked seizures (or one unprovoked seizure with a high chance of another), so the focus shifts from treating a single event to managing a long-term condition.
There is no single “best” epilepsy hospital; what matters is choosing a center that holds the top accreditation for complex epilepsy care (e.g., NAEC Level 4 in the U.S. or an equivalent comprehensive program elsewhere), performs a high number of epilepsy surgeries with good outcomes, and has a multidisciplinary team and active research program. Examples that fit these benchmarks include Mayo Clinic and Cleveland Clinic (USA), King’s College Hospital/UCL in London (UK), University of Bonn (Germany), Pitié-Salpêtrière (France), Toronto Western Hospital (Canada), and Tokyo University Hospital (Japan). Ask your neurologist or local epilepsy foundation which accredited comprehensive center is closest and best suited to your insurance, travel limits, and whether you need adult or pediatric care.
There’s no single “best” exercise for epilepsy—the goal is to choose any activity you enjoy (brisk walking, cycling, swimming with a buddy, light weights, yoga) and do it regularly enough to meet general health targets of ~150 minutes of moderate movement plus two strength sessions weekly. Apply a safety layer: take medications on schedule, avoid personal triggers, wear a medical ID, and have supervision for water or height-related sports; studies and international guidelines show this approach improves fitness, mood, and often reduces seizures without added risk. Always confirm details with your neurologist so the plan fits your seizure pattern and other health factors.