50 Participants Needed

Advanced MRI Techniques for Pediatric Epilepsy

(DTI/SEP Trial)

MN
Bangning Yu, MD, PhD profile photo
Overseen ByBangning Yu, MD, PhD
Age: < 65
Sex: Any
Trial Phase: Academic
Sponsor: The University of Texas Health Science Center, Houston
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

To determine the utility of diffusion tensor magnetic resonance imaging in the preoperative workup of children with intractable epilepsy referred for surgery.

Do I need to stop my current medications for this trial?

The trial information does not specify whether you need to stop taking your current medications.

Is MRI safe for use in epilepsy patients?

An observational study found that using MRI to localize implanted intracranial electrodes in patients with refractory epilepsy is safe when using a 1.5 Tesla MR scanner.12345

How does the treatment in the Advanced MRI Techniques for Pediatric Epilepsy trial differ from other treatments for epilepsy?

This treatment uses advanced MRI techniques to better identify and understand the brain areas involved in epilepsy, which can help tailor surgical approaches to each patient. Unlike standard imaging, these techniques provide more detailed information about brain structure and function, potentially improving the accuracy of epilepsy diagnosis and treatment planning.678910

What data supports the effectiveness of the treatment Observation, Observation, Watchful waiting, Active surveillance for pediatric epilepsy?

The research highlights that advanced MRI techniques, such as functional MRI and diffusion tensor imaging, are crucial in accurately identifying brain areas involved in epilepsy, which can guide treatment decisions and potentially improve outcomes for children with epilepsy.3461011

Who Is on the Research Team?

MN

Manish N Shah, M.D.

Principal Investigator

UTHealth Medical School

Are You a Good Fit for This Trial?

This clinical trial is specifically for children who have been diagnosed with intractable epilepsy, which means their seizures are not controlled by medication. The study is open to those referred for surgery due to the severity of their condition.

Inclusion Criteria

My child has epilepsy that doesn't respond to treatment.

Exclusion Criteria

I do not have uncontrollable epilepsy.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Preoperative Imaging

Participants undergo standard preoperative MRI imaging, including a 15-minute set of functional connectivity and diffusion tensor sequences

1 week
1 visit (in-person)

Postoperative Imaging

Participants undergo standard postoperative MRI imaging to assess changes

1 week
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after imaging procedures

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Observation
Trial Overview The trial is observing how useful diffusion tensor magnetic resonance imaging (DT-MRI) can be in preparing for surgery in these children. DT-MRI is a type of brain scan that helps doctors see how water moves along neural pathways.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Observational cohortExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

The University of Texas Health Science Center, Houston

Lead Sponsor

Trials
974
Recruited
361,000+

Published Research Related to This Trial

Neuroimaging is essential in evaluating pediatric epilepsy, helping in diagnosis, follow-up, and presurgical assessment by identifying cerebral lesions and alterations associated with focal epilepsy.
Recent advancements in imaging techniques, such as diffusion-weighted imaging (DWI) and functional MRI (fMRI), enhance the accuracy of lesion detection and help map critical brain areas, which is crucial for planning safe epilepsy surgeries and minimizing risks of new complications.
Narrative review of epilepsy: getting the most out of your neuroimaging.De Vito, A., Mankad, K., Pujar, S., et al.[2021]
In a study of 56 MRI-negative patients with intractable focal epilepsy who had failed initial surgery, MRI post-processing identified potential targets for re-evaluation in 15 patients, suggesting that advanced imaging techniques can reveal previously overlooked areas for intervention.
Among those with identified targets, patients who underwent further surgery on the unresected regions showed promising outcomes, with two out of ten becoming seizure-free, highlighting the importance of using MRI post-processing to guide surgical decisions in challenging cases.
Re-review of MRI with post-processing in nonlesional patients in whom epilepsy surgery has failed.Wang, ZI., Suwanpakdee, P., Jones, SE., et al.[2018]
MRI is crucial for diagnosing focal epilepsies before surgery, but 16 to 47% of patients may have MRI-negative results, complicating treatment decisions.
Post-operative seizure freedom rates for MRI-negative patients are generally between 40 to 50%, but advancements in imaging techniques and multimodal approaches may enhance candidate selection and outcomes.
Outcome after epilepsy surgery in children with MRI-negative non-idiopathic focal epilepsies.Bast, T.[2013]

Citations

Narrative review of epilepsy: getting the most out of your neuroimaging. [2021]
Re-review of MRI with post-processing in nonlesional patients in whom epilepsy surgery has failed. [2018]
Outcome after epilepsy surgery in children with MRI-negative non-idiopathic focal epilepsies. [2013]
Subtraction Ictal SPECT coregistered to MRI (SISCOM) as a guide in localizing childhood epilepsy. [2022]
Proposal for a magnetic resonance imaging protocol for the detection of epileptogenic lesions at early outpatient stages. [2022]
Voxel-based morphometric magnetic resonance imaging (MRI) postprocessing in MRI-negative epilepsies. [2019]
Safety of MRI in the localization of implanted intracranial electrodes for refractory epilepsy. [2021]
Neuroradiological findings in patients with "non-lesional" focal epilepsy revealed by research protocol. [2019]
[Cerebral imaging in childhood epilepsy: what's new?]. [2006]
10.United Statespubmed.ncbi.nlm.nih.gov
Neuroimaging in pediatric epilepsy. [2022]
Diagnostic Accuracy of Epilepsy-dedicated MRI with Post-processing. [2023]
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