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MRI Imaging for Thymoma

N/A

Waitlist Available

Led By Marcelo F Benveniste

Research Sponsored by M.D. Anderson Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

All adult patients scheduled to meet with a thoracic surgeon from MD Anderson Cancer Center (ACC) for resection of newly diagnosed thymoma or thymoma recurrence in the chest and scheduled for surgery

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 10 years

Awards & highlights

Study Summary

This trial is testing whether MRI is more accurate than CT in imaging the inside of the chest in patients with thymoma.

Who is the study for?

This trial is for adults with newly diagnosed or recurrent thymoma who are scheduled for surgery at MD Anderson Cancer Center. It's not open to those under 18, pregnant women, patients with metal in their chest or pacemakers, known allergies to MRI contrast agents (gadolinium), or severe kidney issues.Check my eligibility

What is being tested?

The study is testing the effectiveness of an MRI scan versus a standard CT scan in accurately imaging and assessing the spread of thymoma within the chest before surgical removal.See study design

What are the potential side effects?

There may be minimal side effects from the MRI procedure itself; however, individuals allergic to gadolinium might experience reactions if contrast is used. Kidney function could also be affected by contrasts used during imaging.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am scheduled for surgery at MD Anderson for a new or recurring thymoma.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 10 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 10 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 10 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Accuracy of magnetic resonance imaging (MRI) staging

Secondary outcome measures

Accuracy of fast novel MRI sequences

Accuracy of phrenic nerve paralysis by functional MRI

Side effects data

From 2022 Phase 3 trial • 53 Patients • NCT00033293

19%

87900-Vomiting(targeted toxicity)

15%

11400-Agitation

11600-Alanine aminotransferase increased

16800-Bladder infection

44800-Infections and infestations - Other specify

58700-Nystagmus

15000-Aspartate aminotransferase increased

88500-White blood cell decreased

15300-Ataxia

33900-Fever

25700-Diarrhea

43100-Hypokalemia

69700-Rash maculo-papular(targeted toxicity)

13200-Anemia

33300-Febrile neutropenia

57600-Nausea(targeted toxicity)

20500-Catheter related infection

58300-Neutrophil count decreased

41300-Hypercalcemia

41400-Hyperglycemia(targeted toxicity)

41600-Hyperkalemia

42600-Hypoalbuminemia

42700-Hypocalcemia

64400-Personality change

41500-Hyperhidrosis

13500-Anorexia

100%

80%

60%

40%

20%

Study treatment Arm

Arm I (Chemotherapy, Immunoglobulin Therapy)

Arm II (Chemotherapy, Observation)

Trial Design

1Treatment groups

Experimental Treatment

Group I: Diagnostic (MRI, diaphragm fluoroscopy)Experimental Treatment2 Interventions

Patients undergo an MRI scan over 45-60 minutes and a diaphragm fluoroscopy 30 days before surgery.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Magnetic Resonance Imaging

2017

Completed Phase 3

~1190

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

National Cancer Institute (NCI)NIH

13,661 Previous Clinical Trials

40,924,382 Total Patients Enrolled

22 Trials studying Thymoma

2,713 Patients Enrolled for Thymoma

M.D. Anderson Cancer CenterLead Sponsor

2,972 Previous Clinical Trials

1,787,259 Total Patients Enrolled

3 Trials studying Thymoma

76 Patients Enrolled for Thymoma

Marcelo F BenvenistePrincipal InvestigatorM.D. Anderson Cancer Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any vacancies for individuals to join this medical experiment?

"Clinicaltrials.gov confirms that this assessment is no longer seeking volunteers, as it was initially posted on June 8th 2011 and last edited on September 22nd 2022. However, 36 other medical studies are currently enrolling patients."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

An Investigational Scan (MRI) in Imaging Patients With Newly-Diagnosed or Recurrent Thymoma

2011. "An Investigational Scan (MRI) in Imaging Patients With Newly-Diagnosed or Recurrent Thymoma". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03968315.

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