ZTE MRI vs CT for Craniosynostosis
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores the effectiveness of a new imaging technique, Zero Echo Time Magnetic Resonance Imaging (ZTE MRI), compared to the usual CT scans for diagnosing craniosynostosis, a condition where the skull bones fuse too early. The goal is to determine if ZTE MRI can provide the clear images needed for diagnosis without the radiation used in CT scans. Pediatric patients advised to undergo a CT scan for craniosynostosis may be suitable candidates for this study. As an unphased trial, it offers a unique opportunity for patients to contribute to the advancement of safer diagnostic methods without radiation exposure.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What prior data suggests that Zero Echo Time Magnetic Resonance Imaging (ZTE MRI) is safe for diagnosing craniosynostosis?
Research has shown that Zero Echo Time (ZTE) MRI is a promising and patient-friendly imaging technique. Studies have found that ZTE MRI excels at examining brain structures and offers a safer alternative to traditional methods. Unlike CT scans, ZTE MRI does not use radiation, providing a significant safety benefit, especially for children.
ZTE MRI is also effective at imaging bones, which is crucial for diagnosing conditions like craniosynostosis, a skull abnormality. Evidence suggests that ZTE MRI provides clear images without the risks of radiation exposure, making it a safe option for sensitive cases, such as those involving children.12345Why are researchers excited about this trial?
Researchers are excited about Zero Echo Time Magnetic Resonance Imaging (ZTE MRI) for craniosynostosis because it offers a radiation-free alternative to the standard CT scans typically used for this condition. Unlike CT scans, which involve exposure to radiation, ZTE MRI uses magnetic resonance to create detailed images, making it safer for pediatric patients. Additionally, ZTE MRI can capture high-resolution images of the skull and brain, potentially providing more detailed diagnostic information without the risks associated with radiation exposure. This makes ZTE MRI an appealing option for safely and effectively diagnosing craniosynostosis in children.
What evidence suggests that ZTE MRI is effective for diagnosing craniosynostosis?
Research has shown that Zero Echo Time Magnetic Resonance Imaging (ZTE MRI) is a promising method for imaging bones, particularly in the head and neck. Studies have found that ZTE MRI captures clear images of tissues typically difficult to visualize with regular MRI. This technique works well for examining skull bones, such as in cases of craniosynostosis, where the skull bones fuse prematurely. A small study demonstrated that ZTE MRI could be useful in routine medical care for assessing skull and base bone issues. This trial will evaluate ZTE MRI as a potential alternative or addition to CT scans for diagnosing craniosynostosis.12367
Who Is on the Research Team?
Julie B Guerin, MD
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
This trial is for children and teenagers aged 0-18 who may have craniosynostosis, a condition affecting skull growth. They must be considered for potential skull reconstruction surgery and able to undergo both MRI and CT scans within a specific timeframe.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Imaging
Pediatric patients receive a Zero Echo Time Magnetic Resonance Imaging (ZTE MRI) after having a clinically indicated CT
Follow-up
Participants are monitored for concordance between ZTE and CT imaging diagnosis
What Are the Treatments Tested in This Trial?
Interventions
- Zero Echo Time Magnetic Resonance Imaging (ZTE MRI)
Trial Overview
The study aims to compare the effectiveness of Zero Echo Time Magnetic Resonance Imaging (ZTE MRI) with traditional CT scans in diagnosing craniosynostosis in pediatric patients.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Pediatric patients that have gotten a clinically indicated CT within a 6 week time period will receive a Zero Echo Time Magnetic Resonance Imaging (ZTE MRI)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
Citations
Zero-TE MRI: principles and applications in the head and neck
Zero echo-time (ZTE) MRI is a novel imaging technique that utilizes ultrafast readouts to capture signal from short-T2 tissues.
Comparative Analysis of Zero Echo-time MRI and CT for ...
Zero echo-time (ZTE) MRI (K132376) is an emerging technique that has been shown to adequately image bone and will likely allow eventual ...
Utility of zero echo time (ZTE) sequence for assessing bony ...
The pilot study suggests strong potential for integrating the ZTE imaging into standard care for skull base and calvarial bony lesions assessment.
Imaging Modalities in Craniosynostosis: A Systematic ...
Each imaging modality (3DCT, MRI, Ultrasound, 3DSPG) was evaluated across key diagnostic outcomes: suture visualization, bone thickness and ...
Comparing MRI to CT on Pediatric Craniosynostosis.
The purpose of this study is to develop and test the effectiveness and diagnostic quality of Zero Echo Time Magnetic Resonance Imaging (ZTE MRI) in comparison ...
Utility of zero echo time (ZTE) sequence for assessing bony ...
ZTE MRI is invaluable for assessing craniofacial abnormalities, including skull deformities like plagiocephaly and craniosynostosis. It offers ...
MRI-based Zero Echo Time and Black Bone Pseudo-CT ...
Both zero echo time and black bone pseudo-CT MRI sequences had high diagnostic accuracy in detecting osteolytic myeloma lesions; black bone outperformed zero ...
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