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Procedure

MRI for Glioblastoma

N/A

Recruiting

Led By Benjamin M Ellingson

Research Sponsored by Jonsson Comprehensive Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients > 18 years of age

Patients with newly diagnosed, suspected or recurrent glioblastoma (GBM) patients with enhancing tumors greater than 1.5 mL clinically indicated for surgical resection. Recurrent GBM must have occurred more than 3 months after the end of radiation therapy per Response Assessment in Neuro-Oncology Criteria (RANO) guidelines

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 5 years

Awards & highlights

Study Summary

This trial uses MRI scans to study brain tumor biology in people with glioblastoma that can be surgically removed. It aims to find out which patients will benefit from a drug therapy to treat the cancer.

Who is the study for?

This trial is for adults over 18 with new or returning glioblastoma, a type of brain tumor. Participants must have tumors larger than 1.5 mL that can be surgically removed and should not have had radiation therapy within the last three months.Check my eligibility

What is being tested?

The study uses MRI scans to understand brain tumor biology in glioblastoma patients eligible for surgery. It aims to find out which patients might benefit from a drug called bevacizumab by analyzing MRI images and biomarkers.See study design

What are the potential side effects?

Since this trial involves MRI scans and biospecimen collection rather than testing new drugs, side effects are minimal but may include discomfort during imaging or at the biospecimen collection site.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am older than 18 years.

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I have a glioblastoma larger than 1.5 mL and need surgery, or my glioblastoma has recurred 3 months after radiation.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

DCN expression among Mesenchymal-Like (MES-like) cells

DCN expression correlated to ADCL

Decorin (DCN) expression

+1 more

Secondary outcome measures

DCN protein concentration in blood plasma

Trial Design

1Treatment groups

Experimental Treatment

Group I: Screening (MRI)Experimental Treatment3 Interventions

Patients undergo one MRI scan over approximately 1 hour prior to surgery.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Magnetic Resonance Imaging

2017

Completed Phase 3

~1190

Biospecimen Collection

2004

Completed Phase 2

~1700

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Jonsson Comprehensive Cancer CenterLead Sponsor

361 Previous Clinical Trials

27,762 Total Patients Enrolled

17 Trials studying Glioblastoma

476 Patients Enrolled for Glioblastoma

National Cancer Institute (NCI)NIH

13,672 Previous Clinical Trials

40,926,391 Total Patients Enrolled

323 Trials studying Glioblastoma

23,098 Patients Enrolled for Glioblastoma

Benjamin M EllingsonPrincipal InvestigatorUCLA / Jonsson Comprehensive Cancer Center

2 Previous Clinical Trials

68 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is recruitment currently taking place for this research project?

"The details on clinicaltrials.gov substantiate that this trial is currently enrolling participants, starting from the date of its initial posting on April 14th 2022 and last modified on October 13th 2023."

Answered by AI

How many individuals are currently involved in the experiment?

"Affirmative, there is evidence on clinicaltrials.gov that this trial has been recruiting participants since April 14th 2022 and was recently updated in October 13th 2023. Only 50 individuals need to be enrolled across one site for the study to proceed."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Magnetic Resonance Imaging for Improving Knowledge of Brain Tumor Biology in Patients With Resectable Glioblastoma

2022. "Magnetic Resonance Imaging for Improving Knowledge of Brain Tumor Biology in Patients With Resectable Glioblastoma". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06090903.

All > Glioblastoma Long Beach > Brain Tumor