ST-MRI for Brain Tumors
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. However, it does mention that participants should not have had prior chemotherapy or radiation therapy.
What data supports the effectiveness of the treatment ST-MRI for Brain Tumors?
Research shows that Chemical Exchange Saturation Transfer (CEST) MRI, a part of ST-MRI, has been effective in monitoring brain tumor metabolism and response to therapy, particularly in glioblastoma, a type of brain cancer. CEST MRI techniques have been used to track important tumor metabolites and assess treatment response, indicating its potential usefulness in brain tumor management.12345
Is ST-MRI safe for use in humans?
How is the ST-MRI treatment for brain tumors different from other treatments?
ST-MRI, using chemical exchange saturation transfer (CEST), is unique because it provides detailed images of brain tumor metabolism by mapping specific molecules like glutamate and lactate. This technique offers a non-invasive way to assess tumor metabolism and microenvironment, which is not typically available with standard MRI methods.12389
What is the purpose of this trial?
Low grade gliomas (LGGs) are malignant, infiltrative and incurable brain tumours that typically present in the younger population. This project proposes to use non-contrast metabolic "Saturation Transfer" (ST)-MRI to evaluate LGG tumour progression and aims to predict early changes in LGG. Early identification of LGG patients whose tumours will progress will permit early interventions. ST-MRI does not involve any intravenous injection of contrast and which acquires metabolic information not seen by standard MRI.
Research Team
Greg J Stanisz, PhD
Principal Investigator
Sunnybrook Health Sciences Centre
Eligibility Criteria
This trial is for individuals aged 12 or older with suspected or confirmed low-grade glioma who don't need immediate treatment. They must be able to undergo MRI scans and be followed at specified health centers. Pregnant individuals or those needing post-surgical chemotherapy/radiation are excluded.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Imaging
Participants undergo Saturation Transfer (ST)-MRI during their standard of care imaging visits
Follow-up
Participants are monitored for tumour progression using ST-MRI and standard MRI
Treatment Details
Interventions
- Saturation Transfer (ST)-MRI
Find a Clinic Near You
Who Is Running the Clinical Trial?
Sunnybrook Health Sciences Centre
Lead Sponsor