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ST-MRI for Brain Tumors

N/A
Recruiting
Led By Greg J Stanisz, PhD
Research Sponsored by Sunnybrook Health Sciences Centre
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
No need for upfront treatment (surgery, chemotherapy, and/or radiation therapy)
Diagnosed with Cohort A (pre-surgical): Suspected LGG (oligodendroglioma or astrocytoma), based on any combination of histological, molecular, radiological, and/or clinical findings; or Cohort B (post-surgical): IDH1/2-mutant or IDH-wildtype (WT) low-grade glioma candidate for observation
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 6 years, from date of initial (st)-mri scan until the date of progression
Awards & highlights

Study Summary

This trial will use MRI to help identify and intervene early with brain tumours that affect younger people, without the need for contrast injections.

Who is the study for?
This trial is for individuals aged 12 or older with suspected or confirmed low-grade glioma who don't need immediate treatment. They must be able to undergo MRI scans and be followed at specified health centers. Pregnant individuals or those needing post-surgical chemotherapy/radiation are excluded.Check my eligibility
What is being tested?
The study tests a non-contrast metabolic 'Saturation Transfer' (ST)-MRI technique on patients with low-grade gliomas to detect early tumor progression, without the use of intravenous contrast agents.See study design
What are the potential side effects?
Since ST-MRI is a non-invasive imaging technique that doesn't involve drugs or radiation, it's generally considered safe with minimal side effects related mainly to discomfort from lying still during the scan.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I don't require immediate surgery, chemotherapy, or radiation.
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I am diagnosed with a type of brain tumor either before or after surgery, based on specific tests.
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I have not had chemotherapy or radiation therapy before.
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I am at least 12 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 6 years, from date of initial (st)-mri scan until the date of progression
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 6 years, from date of initial (st)-mri scan until the date of progression for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
The time-to-progression as measured by Saturation Transfer (ST)-MRI (based on a change in volume or parameter value of over 10%) relative to the time-to-progression as measured by standard MRI using RANO-LGG.
Secondary outcome measures
Accuracy of Saturation Transfer (ST)-MRI for detecting progression (based on a change in volume or parameter value of over 10%).

Trial Design

1Treatment groups
Experimental Treatment
Group I: ST-MRI scansExperimental Treatment1 Intervention
All patients will undergo Saturation Transfer (ST)-MRI during their standard of care imaging visits (or within 14 days of their standard MRI).

Find a Location

Who is running the clinical trial?

Sunnybrook Health Sciences CentreLead Sponsor
656 Previous Clinical Trials
1,551,207 Total Patients Enrolled
Greg J Stanisz, PhDPrincipal InvestigatorSunnybrook Health Sciences Centre
1 Previous Clinical Trials
10 Total Patients Enrolled

Media Library

ST-MRI scans Clinical Trial Eligibility Overview. Trial Name: NCT05996653 — N/A
Low Grade Glioma Research Study Groups: ST-MRI scans
Low Grade Glioma Clinical Trial 2023: ST-MRI scans Highlights & Side Effects. Trial Name: NCT05996653 — N/A
ST-MRI scans 2023 Treatment Timeline for Medical Study. Trial Name: NCT05996653 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research endeavor currently seeking participants?

"Indeed, according to clinicaltrials.gov this trial is still actively searching for volunteers. The project was initially posted on August 12th 2022 and has been recently amended in August 10th 2023. Two sites are recruiting 100 participants respectively."

Answered by AI

How many participants are currently involved in this clinical experiment?

"Affirmative. Clinicaltrials.gov attests that this experiment, which was first advertised on August 12th 2022, is actively recruiting individuals to participate in the study. A total of 100 volunteers are needed to be recruited from 2 separate medical centres."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
CEST in Low-grade Glioma Study
Dr. MaryJane Lim Fat 2022. "CEST in Low-grade Glioma Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05996653.
~67 spots leftby Aug 2028
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