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Hyperpolarized 129Xe MRI for Lung Disease

Phase 1
Recruiting
Led By Peter Niedbalski, PHD
Research Sponsored by Mario Castro, MD, MPH
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Subjects with Lung Disease: No acute worsening of pulmonary function in the past 30 days
Healthy Volunteers: Subject has no diagnosed pulmonary conditions
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 1
Awards & highlights

Study Summary

This trial will test if HP 129Xe gas MRI can help assess regional pulmonary function.

Who is the study for?
This trial is for healthy individuals and those with various lung diseases who can read English or Spanish. Participants must not have had a recent worsening of their condition, be able to hold their breath for about 16 seconds, and have an oxygen saturation above 88%. Pregnant or lactating individuals, those unable to fit into the MRI equipment, or with cognitive issues preventing consent are excluded.Check my eligibility
What is being tested?
The study is testing hyperpolarized Xenon (Xe129) gas MRI as a method to evaluate lung function in both healthy people and patients with pulmonary conditions. It aims to develop this imaging technique for better assessment of regional lung function.See study design
What are the potential side effects?
Since the intervention involves only MRI imaging using hyperpolarized Xe129 gas, side effects may include discomfort from holding one's breath during scanning and potential claustrophobia inside the MRI machine.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My lung condition hasn't worsened in the last month.
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I do not have any lung diseases.
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I have been diagnosed with a lung condition by a doctor.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 1
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 1 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
RBC/Barrier Ratio
Secondary outcome measures
ADC
Ventilation Defect Percentage

Trial Design

1Treatment groups
Experimental Treatment
Group I: Hyperpolarized 129XeExperimental Treatment1 Intervention
Administration of hyperpolarized xenon during MRI (up to 1L doses) to develop imaging methods and assess pulmonary function in adults.

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Mario Castro, MD, MPHLead Sponsor
Peter Niedbalski, PHDPrincipal InvestigatorUniversity of Kansas Medical Center
1 Previous Clinical Trials
22 Total Patients Enrolled

Media Library

Hyperpolarized Xe129 Clinical Trial Eligibility Overview. Trial Name: NCT04624490 — Phase 1
Chronic Obstructive Pulmonary Disease Research Study Groups: Hyperpolarized 129Xe
Chronic Obstructive Pulmonary Disease Clinical Trial 2023: Hyperpolarized Xe129 Highlights & Side Effects. Trial Name: NCT04624490 — Phase 1
Hyperpolarized Xe129 2023 Treatment Timeline for Medical Study. Trial Name: NCT04624490 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants are actively engaged in this research program?

"Absolutely. As per the information posted on clinicaltrials.gov, this medical trial is currently recruiting patient volunteers and has done since November 2nd 2020. The study plans to bring in 260 participants across one site of enrollment."

Answered by AI

Is this research endeavor currently enlisting participants?

"Yes, the information on clinicialtrials.gov alludes to this trial's ongoing recruitment efforts; it was first posted in November 2020 and last updated a month ago. Currently, 260 patients are needed at 1 medical centre."

Answered by AI

Has the FDA sanctioned Hyperpolarized Xe129 as a legitimate medical therapeutic?

"Our analysis at Power deems hyperpolarized Xe129 as having a safety rating of 1 due to the fact that this is an early phase trial and there is limited evidence with regards to its efficacy."

Answered by AI

Are there any documented precedents of using Hyperpolarized Xe129 in prior investigations?

"Presently, there are 15 Hyperpolarized Xe129 clinical trials in progress of which none is at the Phase 3 stage. These studies primarily occur in Philadelphia, Pennsylvania but span across 21 distinct locations."

Answered by AI

Who else is applying?

What state do they live in?
Kansas
How old are they?
65+
What portion of applicants met pre-screening criteria?
Met criteria
What site did they apply to?
University of Kansas Medical Center

Why did patients apply to this trial?

I want to possibly help other people with my condition.
PatientReceived 2+ prior treatments
Recent research and studies
clinicaltrials.govStudy
Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease
Mario Castro, MD, MPH 2020. "Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04624490.
All > Pediatric Asthma > Pulmonary Hypertension
~79 spots leftby Oct 2025
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