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Radiation Therapy

LITT + Radiation Therapy for Brain Tumor

N/A
Recruiting
Research Sponsored by University of Maryland, Baltimore
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
History and physical including neurological exam within 30 days prior to registration
Age ≥ 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights

Study Summary

This trial is testing a new combination of Laser Interstitial Thermal Therapy (LITT) and Hypo-fractionated Radiation Therapy to treat patients with newly diagnosed gliomas.

Who is the study for?
This trial is for adults over 18 with newly diagnosed gliomas, a type of brain tumor. They must be able to undergo MRI scans and have a Karnofsky performance status of at least 50%, indicating they can care for themselves. Women who can become pregnant must test negative for pregnancy and use effective contraception during the study.Check my eligibility
What is being tested?
The trial tests a treatment regimen combining Laser Interstitial Thermal Therapy (LITT) and Hypo-fractionated Radiation Therapy on patients with new gliomas. LITT uses lasers to destroy tumor cells, followed by targeted radiation therapy in fewer high-dose sessions.See study design
What are the potential side effects?
Potential side effects may include discomfort or complications from laser surgery, skin irritation or damage from radiation, fatigue, headaches, swelling in the brain area treated, and possible changes in neurological function.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I've had a full physical and neurological exam in the last 30 days.
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I am 18 years old or older.
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I am a woman who can have children and have a recent negative pregnancy test.
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My scans suggest I have a high-grade brain tumor.
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I can do most of my daily activities by myself.
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My recent brain MRI shows a mass, and I am considered for laser therapy.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Adverse Events
Secondary outcome measures
1-year overall survival
Median overall survival
Median progression-free survival
+3 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: LITT with Hypofractionated RTExperimental Treatment2 Interventions
Laser interstitial thermal therapy (LITT) followed by hypo-fractionated radiation therapy, 25Gy/10 fractions.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Hypofractionated Radiation Therapy
2016
Completed Phase 2
~130

Find a Location

Who is running the clinical trial?

University of Maryland, BaltimoreLead Sponsor
685 Previous Clinical Trials
373,014 Total Patients Enrolled
Keep Punching FoundationUNKNOWN
1 Previous Clinical Trials
32 Total Patients Enrolled

Media Library

Hypofractionated Radiation Therapy (Radiation Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT04699773 — N/A
Brain Tumor Research Study Groups: LITT with Hypofractionated RT
Brain Tumor Clinical Trial 2023: Hypofractionated Radiation Therapy Highlights & Side Effects. Trial Name: NCT04699773 — N/A
Hypofractionated Radiation Therapy (Radiation Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04699773 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any openings for individuals to take part in this experiment?

"As indicated on clinicaltrials.gov, this medical trial is currently enrolling patients. The initial posting was made on February 20th 2021 and the latest update occurred April 26th 2022."

Answered by AI

At which sites is the research study being conducted?

"The 5 sites recruiting patients for this trial include UCH Kaufman Cancer Center in Bel Air, Central Maryland Radiation Oncology in Columbia, and the Maryland Proton Treatment Centre located in Baltimore. Additionally, there are two additional locations that are also participating."

Answered by AI

What is the upper boundary for participants in this medical experiment?

"Affirmative. According to the data hosted on clinicaltrials.gov, this medical research is currently recruiting participants since its initial posting in February 20th 2021 and last update on April 26th 2022. 32 patients need to be enrolled from 5 different sites."

Answered by AI
~7 spots leftby Feb 2025