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We started Power when my dad was diagnosed with multiple myeloma, and I struggled to help him access the latest immunotherapy. Hopefully Power makes it simpler for you to explore promising new treatments, during what is probably a difficult time.
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"I've tried several different SSRIs over the past 23 years with no luck. Some of these new treatments seem interesting... haven't tried anything like them before. I really hope that one could work."
"I was diagnosed with stage 4 pancreatic cancer three months ago, metastatic to my liver, and I have been receiving and responding well to chemotherapy. My blood work revealed that my tumor markers have gone from 2600 in the beginning to 173 as of now, even with the delay in treatment, they are not going up. CT Scans reveal they have been shrinking as well. However, chemo is seriously deteriorating my body. I have 4 more treatments to go in this 12 treatment cycle. I am just interested in learning about my other options, if any are available to me."
"My orthopedist recommended a half replacement of my right knee. I have had both hips replaced. Currently have arthritis in knee, shoulder, and thumb. I want to avoid surgery, and I'm open-minded about trying a trial before using surgery as a last resort."
"As a healthy volunteer, I like to participate in as many trials as I'm able to. It's a good way to help research and earn money."
"I changed my diet in 2020 and I’ve lost 95 pounds from my highest weight (283). I am 5’3”, female, and now 188. I still have a 33 BMI. I've been doing research on alternative approaches to continue my progress, which brought me here to consider clinical trials."
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Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range for Phase 2–4 trials (Phase 1 trials often pay substantially more). Further, most trials will cover the costs of a travel to-and-from the clinic.
After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll be sorted into one of the treatment groups, and receive your study drug. For some trials, there is a chance you'll receive a placebo. Across Parkinson trials 30% of clinical trials have a placebo. Typically, you'll be required to check-in with the clinic every month or so. The average trial length for Parkinson is 12 months.
Not all studies recruit healthy volunteers: usually, Phase 1 studies do. Participating as a healthy volunteer means you will go to a research facility several times over a few days or weeks to receive a dose of either the test treatment or a "placebo," which is a harmless substance that helps researchers compare results. You will have routine tests during these visits, and you'll be compensated for your time and travel, with the number of appointments and details varying by study.
The phase of a trial reveals what stage the drug is in to get approval for a specific condition. Phase 1 trials are the trials to collect safety data in humans. Phase 2 trials are those where the drug has some data showing safety in humans, but where further human data is needed on drug effectiveness. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. As a general rule, Phase 3 trials are more promising than Phase 2, and Phase 2 trials are more promising than phase 1.
Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.
Most recently, we added Accelerated Brain Stimulation for Parkinson's Disease, Gene Therapy for Parkinson's Disease and Gamma-glutamylcysteine for Parkinson's Disease to the Power online platform.
There is no single “best” treatment for Parkinson’s; doctors tailor a plan that usually starts with carbidopa/levodopa (the most effective pill for stiffness and slowness) and may add other drugs, regular exercise/physical therapy, and lifestyle measures. When pills no longer give steady relief, advanced options such as deep-brain stimulation or continuous medication pumps can dramatically smooth movement. Because the right mix depends on your age, symptoms, and other health issues, seeing a movement-disorder specialist is the quickest way to find the combination that’s best for you.
Two early warning clues doctors now watch for are: (1) a fading or lost sense of smell—foods taste bland and familiar odors like coffee or perfume are hard to detect—and (2) “acting out” dreams during sleep (REM-sleep behaviour disorder) where a person kicks, punches, or shouts while dreaming instead of lying still. These changes can appear 5–10 years before the typical shaking or slowness of Parkinson’s; if either symptom shows up without a clear cause, mention it to your doctor because many other issues (allergies, medications, sleep apnea, etc.) can also trigger them.
To keep your medicines working their best, take levodopa on an empty stomach or at least 30–60 min before meals and save most of the day’s protein (meat, eggs, beans, protein shakes) for evening; large protein, iron, or calcium doses given with the pill can block its absorption. If you use an MAO-B inhibitor such as rasagiline or selegiline, limit aged cheeses, cured meats, soy sauce, or other “tyramine-rich” foods because they can spike blood pressure. Beyond these drug-specific issues, a diet built around vegetables, fruit, whole grains, and fish—while going easy on ultra-processed snacks, excess red meat, and large amounts of dairy—has been linked to slower symptom progression, so tailor changes with your doctor or a dietitian.
Scientists have not found one “root” trigger; Parkinson’s usually arises when several things converge. Inherited gene changes (such as in SNCA or LRRK2), long-term exposure to toxins like certain pesticides/solvents, and the natural aging of brain cells can each promote misfolded α-synuclein, malfunctioning mitochondria, and oxidative stress—processes that gradually destroy the dopamine-making neurons. In short, dopamine loss is the final outcome of a complex mix of genetic, environmental, and age-related factors rather than the starting cause.
Doctors use the “5-2-1” rule as a fast way to spot people whose Parkinson’s may no longer be well-controlled by standard tablets: if you need levodopa five or more times a day, still spend two or more waking hours in an “OFF” state (when the medicine has worn off and stiffness, slowness or tremor return), and experience at least one hour of bothersome involuntary movements (“dyskinesia”) daily. Meeting all three points flags “advanced” Parkinson’s and should prompt a conversation with a movement-disorder specialist about options such as adjusting medication, infusion pumps, or deep-brain stimulation.
In large long-term studies, people who do reach Hoehn & Yahr stage 4 usually take about 8–15 years to get there from stage 1, but extremes of only a few years or more than two decades are documented, and roughly one-third never progress that far at all. How quickly someone moves through the stages depends on things like age at diagnosis, the type of symptoms they start with, their response to medication or deep-brain stimulation, and lifestyle factors such as regular exercise.
Ask the person what still brings them joy and what is hardest right now, then focus on two things science shows lift quality of life in Parkinson’s: removing distress (on-time medication, treating depression or poor sleep, making the home and tasks easier so they stay independent) and adding pleasure (regular exercise or dance, music, hobbies, and time with friends or support groups). By pairing practical help with activities that move the body and keep social ties strong, you create the conditions where feeling happier is much more likely.
Carbidopa-levodopa is meant to replace missing dopamine in Parkinson’s disease; in someone without that deficiency it provides no upside and may cause typical drug reactions such as nausea, dizziness from low blood pressure, palpitations, restless or jerky movements, and mood or sleep disturbances. Because these effects can appear after even a few doses and the medicine could complicate the evaluation of other neurologic problems, it should only be taken under a doctor’s direction—not as a trial on your own.
Doctors ask the patient to rapidly tap the tip of the index finger against the thumb for about 10 seconds on each hand; they look not just at speed but at whether the taps quickly get smaller, slower, or irregular. A normal tap remains quick and wide; taps that lose size or rhythm, hesitate, or differ from one side to the other signal the bradykinesia that helps diagnose and monitor Parkinson’s disease.