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Zoledronic Acid for Parkinson's Disease (TOPAZ Trial)
TOPAZ Trial Summary
This trial is testing whether a single infusion of zoledronic acid can help prevent fractures in people with Parkinson's disease or parkinsonism. A total of 3500 participants will be enrolled in the United States.
TOPAZ Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTOPAZ Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.TOPAZ Trial Design
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Who is running the clinical trial?
Media Library
- I am 60 years old or older.I need someone's help to walk.I am 60 years old or older.I have been diagnosed with Parkinson's Disease or parkinsonism by a neurologist.I haven't had nor plan to have any tooth extractions or major dental work soon.The study staff decides that you are not suitable for the study, for example, if you have an uncontrolled drug or alcohol addiction.I have been diagnosed with Parkinson's Disease or a similar condition by a specialist.I have been diagnosed with Parkinson's Disease or a similar condition by a neurologist.I have not taken bisphosphonate drugs in the last year.The text states that the person is willing and able to continue in follow-up for at least 2 years.I am 60 years old or older.I am currently receiving kidney dialysis.I have been diagnosed with multiple myeloma or Paget's disease.I haven't taken any osteoporosis treatments in the last 6 months.I have had a hip fracture in the past.I am 60 years old or older.I have been diagnosed with Parkinson's Disease or a similar condition by a specialist.
- Group 1: Zoledronic acid (ZA)
- Group 2: Placebo
- Drug Has Already Been Approved - The FDA has already approved this drug, and is just seeking more data.
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How many individuals are participating in this clinical research program?
"In order for this clinical trial to commence, 3500 participants must be recruited that meet specified criteria. Those interested in taking part can attend Valley Parkinson Clinic in Los Gatos California or Cook County Health & Hospitals System in Chicago Illinois."
What is the geographical expanse of this research endeavor?
"Valley Parkinson Clinic in Los Gatos, California, Cook County Health & Hospitals System located in Chicago, Illinois and Northwell Health based out of Great Neck, New york are among the 55 sites running this medical trial."
What pathologies has Zoledronic acid been demonstrated to be effective at ameliorating?
"Zoledronic acid (ZA) is generally used to combat malignant tumours and other illnesses such as low bone mineral density, chemotherapy, or osteoporosis."
What former studies have utilized Zoledronic acid (ZA) as a therapeutic agent?
"Currently, there are 36 studies exploring the effects of Zoledronic acid (ZA). 8 of these trials have advanced to Phase 3. Although most research is conducted at Douliu in Yunlin County, 694 medical centres around the world are running experiments with this drug."
Has Zoledronic acid (ZA) been sanctioned by the FDA?
"With Phase 4 trials backing its use, the safety of Zoledronic acid (ZA) has been assessed as a 3 on our scale."
Are there still individuals being included in this research project?
"Affirmative. According to information from clinicaltrials.gov, this medical study commenced on November 15th 2019 and is still actively recruiting participants. An estimated 3500 patients will be taken in at 55 distinct sites for the trial."
Who else is applying?
What state do they live in?
What site did they apply to?
What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
What questions have other patients asked about this trial?
Why did patients apply to this trial?
How responsive is this trial?
Typically responds via
Most responsive sites:
- University of California, Irvine: < 48 hours
Average response time
- < 2 Days
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