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Hormone Replacement Therapy

Hormone Replacement Therapy for Hypothyroidism

Phase 2
Waitlist Available
Research Sponsored by Sention Therapeutics, LLC
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 52
Awards & highlights

Study Summary

This trial is testing a new hormone replacement therapy against the current standard of care to see if it is more effective and has fewer side effects.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week 52
This trial's timeline: 3 weeks for screening, Varies for treatment, and week 52 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Levothyroxine-to-ST-1891 dosing conversion factor
Secondary outcome measures
Percent of patients with a thyroid-stimulating hormone (TSH) level within the standard reference range
Time to TSH normalization

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: ST-1891Experimental Treatment1 Intervention
Group II: LevothyroxineActive Control1 Intervention

Find a Location

Who is running the clinical trial?

Sention Therapeutics, LLCLead Sponsor

Media Library

Levothyroxine (Hormone Replacement Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT05412979 — Phase 2
Hypothyroidism Research Study Groups: ST-1891, Levothyroxine
Hypothyroidism Clinical Trial 2023: Levothyroxine Highlights & Side Effects. Trial Name: NCT05412979 — Phase 2
Levothyroxine (Hormone Replacement Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05412979 — Phase 2
Hypothyroidism Patient Testimony for trial: Trial Name: NCT05412979 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Am I eligible to partake in this clinical research?

"This clinical study seeks to enlist 490 people with a primary hypothyroidism diagnosis and ages ranging from 18-75. To be considered for enrollment, potential participants must have been taking levothyroxine replacement therapy for one year before screening; their dose needs to remain stable in the three months leading up to screening, as well as provide written informed consent."

Answered by AI

Does this medical research include participants below the age of twenty?

"Participants eligible for this medical research must be between 18-75 years old. This study has 3 trials open to minors and 11 specifically tailored towards seniors above 65."

Answered by AI

What is the potential risk of administering ST-1891 to patients?

"Due to being a Phase 2 trial and lacking any data that proves efficacy, ST-1891 was assigned a safety rating of 2 by the Power team."

Answered by AI

Are there still vacancies to participate in this research experiment?

"Clinicaltrials.gov confirms that this prospective study, first posted on April 29th 2022 and last updated November 9th of the same year, is not actively recruiting at present. Nonetheless, there are 13 other trials still seeking participants for their research."

Answered by AI

How many health care centers are currently running this experimental research?

"This clinical trial is presently taking place in 38 distinct locations, spanning from Chesterfield to Denver and beyond. To reduce the amount of travelling necessary for enrollment, it would be beneficial to pick a site near you."

Answered by AI

Who else is applying?

What state do they live in?
North Carolina
Tennessee
Georgia
Other
How old are they?
65+
18 - 65
What site did they apply to?
Sention Investigational Site
Other
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
How many prior treatments have patients received?
0
3+

Why did patients apply to this trial?

I would love to have a medication that would help with some better energy levels and all around well being ! Have been taking Leothroyxine for 20 years and the last 10 has not helped much and very hard to lose weight.
PatientReceived 2+ prior treatments
I’ve been on 50 mcg Levothyroxine for 13 years. Although my TSH bloodwork tests as “normal,” I continue to suffer from many hypothyroid symptoms. Seems the only thing the current med does is check the “normal range” box. I want to feel better and help others with this feel better, too.
PatientReceived 2+ prior treatments

What questions have other patients asked about this trial?

How often are visits required?
PatientReceived 1 prior treatment
Recent research and studies
clinicaltrials.govStudy
A Study Evaluating the Safety and Efficacy of Hormone Replacement Therapy With ST-1891 Compared to Levothyroxine in Patients With Primary Hypothyroidism
2022. "A Study Evaluating the Safety and Efficacy of Hormone Replacement Therapy With ST-1891 Compared to Levothyroxine in Patients With Primary Hypothyroidism". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05412979.
All > Thyroid
~168 spots leftby Apr 2025
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