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Rucaparib + Radiation for Breast Cancer
Study Summary
This trial is testing if a study drug called Rucaparib is safe to be given with a type of radiation therapy that is commonly used to treat women with this form of breast cancer.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- If you are a woman who could become pregnant, you need to have a negative pregnancy test within the 14 days before starting the study treatment.I am using two birth control methods or am not having sex to avoid pregnancy during the study.I still have visible tumor or cancer cells at the surgery edge that weren't removed.I have taken PARP inhibitors before radiation therapy.I have never had radiation therapy on the same side breast or nearby lymph nodes.I have not had cancer treatments for at least 2 weeks and any side effects have gone.I do not have any major health issues that could worsen due to the study.I have triple-negative breast cancer with remaining signs after chemotherapy.My breast cancer is hormone-receptor positive, HER2 negative, and still large or spread to lymph nodes after chemotherapy.I had surgery to remove my breast cancer and check the lymph nodes under my arm.I am expected to live more than 6 months and can do most of my daily activities.I am willing to stop any cancer-killing drugs or biological treatments 2 weeks before starting radiation therapy.My blood, kidney, and liver functions are all within normal ranges.You are still experiencing side effects from other medications.I can swallow and keep down pills.You are currently taking other experimental medications.My cancer fully responded to chemotherapy before surgery.You have had allergic reactions to drugs similar to rucaparib.I am a woman and I am 18 years old or older.
- Group 1: Rucaparib Administered With Radiation
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How efficacious is Rucaparib for individuals seeking medical aid?
"The safety profile of Rucaparib is estimated to be a 1 since this trial only exists in the early stages. There is limited information available regarding both efficacy and security."
Can you elaborate on any other research projects that have been conducted utilizing Rucaparib?
"Rucaparib was initially investigated in 2015 at The Royal Marsden NHS Foundation Trust located in Downs Road, Sutton. Since that seminal moment of discovery there have been 157 concluded clinical trials and 34 ongoing studies, the majority of which are being conducted out of Norwalk, Connecticut."
Is this research a pioneering endeavor?
"Rucaparib has been the focus of 34 distinct clinical trials in 831 cities and 34 nations since Clovis Oncology, Inc. initiated its Phase 2 drug approval process with a trial involving 924 participants back in 2015; these experiments have cumulatively included over 150 separate studies."
Is this research investigation accepting participants?
"Clinicaltrials.gov divulges that this clinical investigation is currently not accepting volunteers, despite having been initially posted on May 23rd 2018 and last modified on August 31st 2022. Though the trial isn't open to enrollments at present, there are 2,697 other trials actively searching for study participants."
How many venues are currently managing this experiment?
"Presently, this study has 8 enrolment sites distributed across Norwalk, New york and Commack. It is recommended to choose the closest one to save time on travelling should you decide to join in."
What is the upper bound of participants for this trial?
"This study is currently not setting forth to look for participants. As it was initially posted on May 23, 2018 and last updated August 31 2022, other trials may be more suitable. There are 2663 clinical studies actively seeking patients with breast cancer while 34 research projects involving Rucaparib are presently hosting enrolments."
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