Speech-motor behavioral testing
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how the cerebellum, a part of the brain, contributes to speech learning and correction in individuals with cerebellar ataxia, a condition causing coordination problems, and in healthy individuals. Participants will engage in speaking tasks while undergoing MRI (Magnetic Resonance Imaging) scans to examine brain activity. Some may also experience TMS (Transcranial Magnetic Stimulation), a technique that briefly influences brain function. Those with cerebellar ataxia and healthy volunteers with normal speech and hearing and no other neurological issues may qualify. As an unphased trial, this study offers participants the chance to contribute to groundbreaking research on brain function and speech.
Will I have to stop taking my current medications?
The trial information does not specify if you need to stop taking your current medications. However, if you are a healthy volunteer, certain medications might be a concern for TMS participation. It's best to discuss your specific medications with the study team.
What prior data suggests that TMS and MRI are safe for studying cerebellar ataxia?
Research has shown that transcranial magnetic stimulation (TMS) is generally well-tolerated by people with cerebellar ataxia. TMS is a non-invasive method that uses magnetic fields to stimulate the brain. Most participants in a study experienced only mild side effects, such as slight headaches or discomfort at the stimulation site, which usually resolved quickly. Another review supports these findings, noting that serious side effects are rare.
Magnetic resonance imaging (MRI) is a commonly used imaging technique considered safe. It uses strong magnets and radio waves to create detailed pictures of the brain. MRI does not involve radiation, and most people tolerate it well. Some might feel a bit uncomfortable or claustrophobic inside the MRI machine, but this can be managed.
Overall, both TMS and MRI have been shown to be safe for humans, with only minor and temporary side effects reported in studies.12345Why are researchers excited about this trial?
Researchers are excited about using TMS (Transcranial Magnetic Stimulation) and MRI (Magnetic Resonance Imaging) for cerebellar ataxia because these methods offer new ways to understand and potentially manage this condition. Unlike standard treatments, which often focus on symptom management through medication and physical therapy, TMS provides a non-invasive way to stimulate brain areas that might improve motor functions. MRI helps researchers to visualize changes in brain activity and structure, offering insights into how cerebellar ataxia affects the brain. Together, these techniques could lead to breakthroughs in how we understand and treat cerebellar ataxia, offering hope for more effective interventions in the future.
What evidence suggests that this trial's approaches could be effective for cerebellar ataxia?
Research has shown that transcranial magnetic stimulation (TMS) can help manage cerebellar ataxia, a movement disorder. In this trial, some participants will receive TMS. Specifically, studies have found that patients who received TMS showed noticeable improvements in their symptoms. This non-invasive method stimulates the brain to enhance coordination. Many patients have experienced better movement, suggesting TMS could be a promising treatment option. Overall, TMS is considered safe and is gaining interest due to its positive effects on ataxia.13467
Who Is on the Research Team?
Richard Ivry, Ph.D.
Principal Investigator
University of California, Berkeley
Ben Parrell, Ph.D.
Principal Investigator
University of Wisconsin, Madison
John F. Houde, Ph.D.
Principal Investigator
University of California, San Francisco
Srikantan S. Nagarajan, Ph.D.
Principal Investigator
University of California, San Francisco
Are You a Good Fit for This Trial?
This trial is for people with cerebellar ataxia who have normal hearing and speak American English, or healthy individuals without physical/neurological issues. Participants must not have seizures, metal implants, heart disease, be pregnant, use hearing aids, or suffer from psychiatric illnesses unrelated to cerebellar damage.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Behavioral Studies
Participants perform speaking tasks while their voice is played back over earphones, and other speaking tasks are conducted.
MRI Studies
MRI is acquired to analyze brain function and anatomy related to speech and the cerebellum.
TMS Studies
In healthy controls, TMS is performed to temporarily disrupt the cerebellum during speaking tasks.
Follow-up
Participants are monitored for safety and effectiveness after the main study activities.
What Are the Treatments Tested in This Trial?
Interventions
- MRI
- Speech-motor behavioral testing
- TMS
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, San Francisco
Lead Sponsor
University of Wisconsin, Madison
Collaborator
National Institute on Deafness and Other Communication Disorders (NIDCD)
Collaborator
University of California, Berkeley
Collaborator