← Back to Search

Cognitive Processing Therapy + Memory Support for PTSD

N/A
Recruiting
Led By Joseph Carpenter, PhD MA
Research Sponsored by Boston University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Current diagnosis of PTSD as determined by the Clinician Administered PTSD Scale for the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

Study Summary

This trial will compare the effects of cognitive processing therapy with and without a memory support intervention to see if the memory support intervention leads to greater memory and learning of therapy content.

Who is the study for?
Adults with PTSD can join this study. They must have a stable dose of psychiatric meds for the last month if they're taking any, and veterans are specifically welcomed. People with unstable bipolar disorder, psychosis, severe substance abuse, or past severe brain injury cannot participate. Also excluded are those with high verbal memory skills or significant cognitive impairment.Check my eligibility
What is being tested?
The trial is testing whether adding Memory Support (MS) to Cognitive Processing Therapy (CPT) helps people remember therapy content better than CPT alone. It's a small-scale test involving 52 adults to see if it's feasible and acceptable to combine these treatments for PTSD.See study design
What are the potential side effects?
Since this trial involves psychological interventions rather than medications, traditional side effects like you might get from drugs aren't expected here. However, participants may experience emotional discomfort as they engage in therapy related to their trauma.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have been diagnosed with PTSD by a professional.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Feasibility assessed by mean CPT Adherence
Feasibility assessed by mean CPT Competence
Feasibility assessed by the Memory Support Rating Scale (MSRS)
+8 more
Secondary outcome measures
Follow-up Change in Depression symptoms assessed by the Patient Health Questionnaire 9-item (PHQ-9)
Follow-up Change in Memory of Therapy Content assessed by the Generalization Task
Follow-up Change in PTSD symptoms assessed by the Clinician Administered PTSD Scale for DSM-5 (CAPS-5)
+16 more
Other outcome measures
Follow-up Change in PTSD-related cognitions assessed by the Posttraumatic Cognitions Inventory - 9-item (PTCI-9)
Follow-up Change in PTSD-related coping self-efficacy assessed by the Trauma Coping Self Efficacy Scale (CSE-T)
Follow-up Change in cognitive complaints assessed by the Cognitive Self-Report Questionnaire - Cognitive subscale (CSRQ-C)
+5 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Cognitive Processing Therapy + Memory Support (CPT + MS)Experimental Treatment2 Interventions
CPT + MS will involve the same treatment strategies as CPT while incorporating deliberate and frequent use of memory and learning support strategies. MS strategies are designed to enhance the memory of specific treatment points, defined as any insight, skill or strategy determined to be important for the patient to remember and/or implement. MS is not designed to enhance memory functioning generally, but rather improve the encoding, consolidation and retrieval of specific components of therapeutic learning.
Group II: Cognitive Processing Therapy (CPT)Active Control1 Intervention
CPT is a manualized, trauma-focused therapy for PTSD. Treatment consists of psychoeducation on the cognitive model of PTSD, identification of trauma-related stuck points (i.e. dysfunctional beliefs), and cognitive challenging techniques to help participants identify more realistic and adaptive ways of viewing their trauma, themselves, and the world.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
MS
2020
N/A
~20
CPT
2012
N/A
~180

Find a Location

Who is running the clinical trial?

VA Boston Healthcare SystemFED
68 Previous Clinical Trials
970,352 Total Patients Enrolled
Boston UniversityLead Sponsor
453 Previous Clinical Trials
9,941,177 Total Patients Enrolled
National Institute of Mental Health (NIMH)NIH
2,777 Previous Clinical Trials
2,674,272 Total Patients Enrolled

Media Library

Cognitive Processing Therapy (CPT) Clinical Trial Eligibility Overview. Trial Name: NCT05310097 — N/A
Post-Traumatic Stress Disorder Research Study Groups: Cognitive Processing Therapy + Memory Support (CPT + MS), Cognitive Processing Therapy (CPT)
Post-Traumatic Stress Disorder Clinical Trial 2023: Cognitive Processing Therapy (CPT) Highlights & Side Effects. Trial Name: NCT05310097 — N/A
Cognitive Processing Therapy (CPT) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05310097 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What objectives is this clinical trial attempting to accomplish?

"Over the span of 12 weeks, this medical trial will measure Treatment Acceptability using a Credibility and Expectancy Questionnaire. Secondary outcomes include Post-treatment Change in Memory of Therapy Content assessed by a Generalization Task, Mid-treatment Skills of Cognitive Therapy (SoCT) - Therapist, as well as Post-treatment Change in Depression symptoms measured through Patient Health Questionnaires 9 Items (PHQ-9)."

Answered by AI

Are there any openings for enrollment in this research initiative?

"According to clinicaltrials.gov, this experiment is not presently enrolling patients; the original post date was November 1st 2022 with recent updates on September 26th of that same year. While no longer actively recruiting, there are currently 318 other trials seeking participants for their studies."

Answered by AI
~67 spots leftby Dec 2026