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Speech-Language Therapy for Aphasia (TERRA Trial)

N/A
Recruiting
Led By Julius Fridriksson, Ph.D.
Research Sponsored by University of South Carolina
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Participants must be between 21-80 years of age.
Participants must be capable of giving informed consent or indicating another to provide informed consent.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up compare baseline score to 6 month follow-up (after treatment) score.
Awards & highlights

TERRA Trial Summary

This trial will compare the efficacy of two types of speech-language therapy for patients with aphasia.

Who is the study for?
This trial is for English-speaking adults aged 21-80 who've had a left hemisphere stroke at least a year ago and can consent to treatment. They must be MRI compatible without metal implants or claustrophobia, and have no history of other brain diseases or severe speech/comprehension impairments.Check my eligibility
What is being tested?
The TERRA study compares two types of speech-language therapy for aphasia after a stroke: one delivered remotely (ART) and the other in-clinic (I-CT). It aims to see if telerehabilitation is as effective as traditional methods.See study design
What are the potential side effects?
Since this trial involves non-invasive therapies focused on language rehabilitation, significant side effects are not anticipated. However, participants may experience fatigue or frustration during therapy sessions.

TERRA Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 21 and 80 years old.
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I can give my own consent or appoint someone to do it for me.
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I had a stroke in the left side of my brain over a year ago.
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I have been primarily speaking English for the last 20 years.

TERRA Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~compare baseline score to 6 month follow-up (after treatment) score.
This trial's timeline: 3 weeks for screening, Varies for treatment, and compare baseline score to 6 month follow-up (after treatment) score. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Speech Production Outcome Score (SPOTS)
Secondary outcome measures
Improvement in overall aphasia severity
Improvement in quality of life

TERRA Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Aphasia Remote Therapy (ART)Experimental Treatment2 Interventions
All participants in this group will receive 3 weeks of daily semantically-focused treatment (semantic feature analysis, semantic barrier task and verb network strengthening therapy) and 3 weeks of daily phonologically-focused treatment (phonological components analysis, phonological production task, phonological judgment task). Participants will be randomized to order of treatment. All treatment will be done remotely with a speech-language pathologist through an online platform using therapy applications. Participants will be provided with teletherapy kits (including an Internet hotspot if needed) to complete the therapy tasks.
Group II: In-Clinic Therapy (I-CT)Active Control2 Interventions
All participants in this group will receive 3 weeks of daily semantically-focused treatment (semantic feature analysis, semantic barrier task and verb network strengthening therapy) and 3 weeks of daily phonologically-focused treatment (phonological components analysis, phonological production task, phonological judgment task). Participants will be randomized to order of treatment. All treatment will be done in person with a speech-language pathologist at the UofSC Aphasia Lab.

Find a Location

Who is running the clinical trial?

University of South CarolinaLead Sponsor
210 Previous Clinical Trials
120,329 Total Patients Enrolled
6 Trials studying Aphasia
521 Patients Enrolled for Aphasia
National Institute on Deafness and Other Communication Disorders (NIDCD)NIH
327 Previous Clinical Trials
178,216 Total Patients Enrolled
36 Trials studying Aphasia
2,599 Patients Enrolled for Aphasia
Medical University of South CarolinaOTHER
930 Previous Clinical Trials
7,393,711 Total Patients Enrolled
5 Trials studying Aphasia
327 Patients Enrolled for Aphasia

Media Library

Phonologically-focused therapy tasks Clinical Trial Eligibility Overview. Trial Name: NCT04682223 — N/A
Aphasia Research Study Groups: Aphasia Remote Therapy (ART), In-Clinic Therapy (I-CT)
Aphasia Clinical Trial 2023: Phonologically-focused therapy tasks Highlights & Side Effects. Trial Name: NCT04682223 — N/A
Phonologically-focused therapy tasks 2023 Treatment Timeline for Medical Study. Trial Name: NCT04682223 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there vacancies in this medical experiment that can be filled by patients?

"Aye, the records on clinicaltrials.gov reveal that this experiment is actively seeking enrollees. The trial was initially posted 5th of May 2021 and most recently changed 2nd of May 2022. This study requires 100 patients at two sites to be recruited."

Answered by AI

Are there specific demographic characteristics that make someone a more suitable candidate for this experiment?

"This research seeks to enrol 100 individuals between the ages of 21 and 80 who have experienced a left-sided stroke at least 12 months prior. Moreover, all participants must meet additional criteria as specified by the study protocol."

Answered by AI

Do you accept participants older than twenty years of age in this research?

"This study requires individuals aged 21 to 80 for inclusion. In contrast, there are 43 trials that accept minors and 1061 which aim to include seniors."

Answered by AI

How many participants are currently included in this medical experiment?

"Indeed, clinicaltrials.gov indicates that this research is actively seeking participants. The project was first advertised on May 5th 2021 and the information has been modified as recently as May 2nd 2022; it needs to recruit 100 individuals from two distinct locations."

Answered by AI
Recent research and studies
~38 spots leftby Jan 2026