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Brain Stimulation for Language Disorder

N/A

Recruiting

Led By Matthew Nelson, PhD

Research Sponsored by University of Alabama at Birmingham

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age 18 and older

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up outcomes will be measured immediately after the intervention

Awards & highlights

Study Summary

This trial studies the effects of electrical stimulation on brain activity during reading.

Who is the study for?

This trial is for adults over 18 with language disorders who are already undergoing brain monitoring (sEEG or ECoG) for epilepsy. Participants must be able to perform control trials of the task effectively.Check my eligibility

What is being tested?

The study tests how sentence types and direct brain stimulation affect language comprehension. Patients read or listen to sentences while their neural activity is recorded, then choose pictures matching the sentences. Later, some receive brain stimulation during this task.See study design

What are the potential side effects?

Since the intervention involves direct brain stimulation in patients already monitored for epilepsy, potential side effects may include discomfort at the electrode site, temporary speech disturbances, or other changes in cognitive functions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am 18 years old or older.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ measured immediately after the intervention

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~measured immediately after the intervention

This trial's timeline: 3 weeks for screening, Varies for treatment, and measured immediately after the intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Behavioral Response - Self-paced word response time for words presented after electrical stimulation

Behavioral Response - Self-paced word response time for words presented before electrical stimulation

Behavioral Response - Self-paced word response time for words presented concomitant with electrical stimulation

+4 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: Intracranial patientsExperimental Treatment2 Interventions

All participants with epilepsy undergoing intracranial monitoring for clinical purposes will be approached to participate in an experiment that is recording-only and an experiment that involves stimulation with simultaneous recording.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

National Institute on Deafness and Other Communication Disorders (NIDCD)NIH

330 Previous Clinical Trials

178,318 Total Patients Enrolled

University of Alabama at BirminghamLead Sponsor

1,590 Previous Clinical Trials

2,281,201 Total Patients Enrolled

Matthew Nelson, PhDPrincipal InvestigatorThe University of Alabama at Birmingham

Media Library

Sentence Type Clinical Trial Eligibility Overview. Trial Name: NCT05283265 — N/A

Language Disorder Research Study Groups: Intracranial patients

Language Disorder Clinical Trial 2023: Sentence Type Highlights & Side Effects. Trial Name: NCT05283265 — N/A

Sentence Type 2023 Treatment Timeline for Medical Study. Trial Name: NCT05283265 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research endeavor still accepting participants?

"Affirmative. Clinicaltrials.gov hosts information that this clinical trial is recruiting, having been first posted on April 8th 2022 and most recently updated on February 23rd 2023. This research requires the enrolment of 153 individuals at a single medical location."

Answered by AI

How many participants have signed up for this experiment?

"Affirmative. Clinicaltrials.gov data confirms that this trial, which was initially publicized on April 8th 2022, is still recruiting participants. 153 individuals are required from a single site for the study to begin."

Answered by AI

Recent research and studies

Journal of NeuroscienceJournal

Broadband Shifts in Local Field Potential Power Spectra Are Correlated with Single-neuron Spiking in Humans

Manning, J. R., J. Jacobs, I. Fried, and M. J. Kahana. 2009. “Broadband Shifts in Local Field Potential Power Spectra Are Correlated with Single-neuron Spiking in Humans”. Journal of Neuroscience. Society for Neuroscience. doi:10.1523/jneurosci.2041-09.2009.

Proceedings of the National Academy of SciencesJournal

Neurophysiological Dynamics of Phrase-structure Building During Sentence Processing

Nelson, Matthew J., Imen El Karoui, Kristof Giber, Xiaofang Yang, Laurent Cohen, Hilda Koopman, Sydney S. Cash, et al.. 2017. “Neurophysiological Dynamics of Phrase-structure Building During Sentence Processing”. Proceedings of the National Academy of Sciences. Proceedings of the National Academy of Sciences. doi:10.1073/pnas.1701590114.

Proceedings of the National Academy of SciencesJournal

Cortical Representation of the Constituent Structure of Sentences

Pallier, Christophe, Anne-Dominique Devauchelle, and Stanislas Dehaene. 2011. “Cortical Representation of the Constituent Structure of Sentences”. Proceedings of the National Academy of Sciences. Proceedings of the National Academy of Sciences. doi:10.1073/pnas.1018711108.

Journal of Neural EngineeringJournal