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Device

Brain Stimulation for Working Memory

N/A

Waitlist Available

Led By Hamdi Eryilmaz, Ph.D.

Research Sponsored by Massachusetts General Hospital

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 hours

Awards & highlights

Study Summary

This trial will use a non-invasive electrical stimulation to modify brain activity and measure its effect on working memory.

Who is the study for?

This trial is for individuals who can give informed consent and are fluent in English. It's designed to explore how working memory functions by using a noninvasive brain stimulation technique.Check my eligibility

What is being tested?

The study tests two types of transcranial alternating current stimulation (tACS): 'Active tACS' which actually modulates brain activity, and 'Placebo tACS', which does not have an active effect. The impact on working memory will be measured with EEG.See study design

What are the potential side effects?

tACS may cause mild side effects such as tingling, itching or discomfort at the electrode sites on the scalp during application. More serious side effects are rare.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Fronto-parietal theta phase synchronization

Theta-gamma cross-frequency coupling

Working memory accuracy

+1 more

Trial Design

4Treatment groups

Experimental Treatment

Placebo Group

Group I: Theta-nested gamma tACS applied during passive task epochsExperimental Treatment1 Intervention

Participants will receive single-session administration of tACS during performance of a working memory task. tACS will be applied during fixation periods between consecutive task trials. EEG will be acquired before and immediately after the intervention.

Group II: Theta-nested gamma tACS applied during memory delaysExperimental Treatment1 Intervention

Participants will receive single-session administration of tACS during performance of a working memory task. tACS will be applied during memory delays. EEG will be acquired before and immediately after the intervention.

Group III: Gamma tACS applied during memory delaysExperimental Treatment1 Intervention

Participants will receive single-session administration of tACS during performance of a working memory task. tACS will be applied during memory delays. The stimulation will be phase locked to the peaks of ongoing theta rhythms of the participant. EEG will be acquired before and immediately after the intervention.

Group IV: Placebo tACS applied during task performancePlacebo Group1 Intervention

Participants will receive single-session administration of placebo tACS during performance of a working memory task. EEG will be acquired before and immediately after the intervention.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor

2,928 Previous Clinical Trials

13,198,323 Total Patients Enrolled

Hamdi Eryilmaz, Ph.D.Principal InvestigatorMassachusetts General Hospital

Media Library

Active tACS (Device) Clinical Trial Eligibility Overview. Trial Name: NCT05923606 — N/A

Working Memory Research Study Groups: Placebo tACS applied during task performance, Theta-nested gamma tACS applied during passive task epochs, Theta-nested gamma tACS applied during memory delays, Gamma tACS applied during memory delays

Working Memory Clinical Trial 2023: Active tACS Highlights & Side Effects. Trial Name: NCT05923606 — N/A

Active tACS (Device) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05923606 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does the minimum age requirement of this trial exceed twenty years?

"This research project is accepting participants who are over the legal age of consent and younger than 35 years old."

Answered by AI

Does this study have any more slots available for enrollees?

"According to the information reported on clinicaltrials.gov, recruitment for this trial has ceased at present. Although registration was initially open from September 1st 2023 and edited lastly on June 27th 2023, there are presently 12 other studies that accept volunteers."

Answered by AI

Is there an opportunity to join this medical test?

"To be considered for this medical study, candidates must possess a proficient level of working memory and fall between the ages of 18 to 35. 32 total participants are needed for successful completion."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Modulation of Brain Oscillations Underlying Working Memory

Hamdi Eryilmaz, PhD 2024. "Modulation of Brain Oscillations Underlying Working Memory". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05923606.